{"id":"W4413014531","doi":"10.1139/bcb-2025-0158","title":"Divergent ERα co-factor landscapes in gynecological cancers: implications for disease progression and therapy","year":2025,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Experimental Program to Stimulate Competitive Research; National Institute of General Medical Sciences; American Cancer Society","keywords":"FOXA1; Ovarian cancer; Breast cancer; GATA3; Estrogen receptor; Estrogen receptor alpha; Biomarker; Cancer; Cancer research; Disease; Oncology; Medicine; Internal medicine; Biology; Transcription factor; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008192108,0.0005390761,0.0008599828,0.001134676,0.000237426,0.0009951034,0.0008071201,0.001596675,0.002735586],"category_scores_gemma":[0.00149207,0.0002079176,0.0004059128,0.001137015,0.0006310116,0.001199946,0.0006394589,0.003095031,0.002457037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001136029,"about_ca_system_score_gemma":0.001237834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140747,"about_ca_topic_score_gemma":0.003588905,"domain_scores_codex":[0.9997788,0.0000489711,0.00002862076,0.00003594703,0.00008295447,0.00002473705],"domain_scores_gemma":[0.9994506,0.0002312632,0.00004260537,0.00001568518,0.0002091908,0.00005054834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001349874,0.00002565421,0.0001829378,0.008619675,0.00008242765,0.0002278663,0.00006743113,0.0002998799,0.001331114,0.007690381,0.3397722,0.6415654],"study_design_scores_gemma":[0.00001338691,0.00003013292,0.000370632,0.001271412,0.0000301502,0.0004605,0.00002636366,0.00003993784,0.0001501292,0.00183715,0.9957594,0.00001075709],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008187183,0.9910727,0.000117155,0.004022851,0.003734988,0.000002866106,0.00003741818,0.00001031038,0.0009198494],"genre_scores_gemma":[0.0007117352,0.9915781,0.0001234652,0.003068032,0.002504785,0.000006470927,0.00006117264,0.000004613678,0.001941587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002735586,"threshold_uncertainty_score":0.009151459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787807726806008,"score_gpt":0.3360574776586615,"score_spread":0.3181794003906014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}