{"id":"W4413018784","doi":"10.1021/acs.biochem.5c00139","title":"Polyphenolic Gallotannins 1,3,6-Tri-O-galloyl-β-<scp>d</scp>-glucose and Corilagin Attenuate IAPP Amyloid Formation and Cytotoxicity by Primarily Targeting Secondary Nucleation","year":2025,"lang":"en","type":"article","venue":"Biochemistry","topic":"Phytochemistry and Bioactivity Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; PROTEO; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Polyphenol; Cytotoxicity; Amyloid (mycology); Biochemistry; Food science; Antioxidant; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004041383,0.0003550288,0.0003381464,0.00005313989,0.0005706071,0.00007205071,0.0001788956,0.0004887598,0.00003402503],"category_scores_gemma":[0.0004226084,0.0003770784,0.00006760318,0.0002103145,0.0003749383,0.000246471,0.0002536924,0.000738559,0.00000855099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001357309,"about_ca_system_score_gemma":0.00009983507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001312432,"about_ca_topic_score_gemma":0.000002148283,"domain_scores_codex":[0.9983902,0.0001030367,0.0003808803,0.0005141644,0.0001420978,0.0004696159],"domain_scores_gemma":[0.9988606,0.0004428167,0.0002211818,0.0001844027,0.00009974498,0.0001912727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009010561,0.0001665963,0.006957266,0.0005799846,0.0001601212,0.000005014122,0.0003627116,0.000001287831,0.9441487,0.0000193848,0.04455918,0.002949648],"study_design_scores_gemma":[0.001244007,0.00003890165,0.00359968,0.00004495942,0.0001270217,0.00001839261,0.0006473662,0.0005874417,0.9456998,0.0001330329,0.04767143,0.0001879599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831367,0.006138469,0.0001116653,0.000757657,0.0001963285,0.0003115899,0.0002796833,0.0001429974,0.008924906],"genre_scores_gemma":[0.9943516,0.001288924,0.0001250645,0.001166674,0.0001906,0.0000527993,0.0002070609,0.0000184843,0.00259874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01121495,"threshold_uncertainty_score":0.9998681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578650042927352,"score_gpt":0.3308004679746454,"score_spread":0.3050139675453719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}