{"id":"W4413018784","doi":"10.1021/acs.biochem.5c00139","title":"Polyphenolic Gallotannins 1,3,6-Tri-O-galloyl-β-<scp>d</scp>-glucose and Corilagin Attenuate IAPP Amyloid Formation and Cytotoxicity by Primarily Targeting Secondary Nucleation","year":2025,"lang":"en","type":"article","venue":"Biochemistry","topic":"Phytochemistry and Bioactivity Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; PROTEO; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Polyphenol; Cytotoxicity; Amyloid (mycology); Biochemistry; Food science; Antioxidant; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003171508,0.0002185982,0.0001227362,0.00006072768,0.0000391582,0.0001191312,0.0001181294,0.0001153499,0.0004146031],"category_scores_gemma":[0.00004930989,0.0000445389,0.0001769369,0.0000587603,0.000105191,0.0001228644,0.0000911342,0.000202451,0.00007481804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682644,"about_ca_system_score_gemma":0.0001283636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132585,"about_ca_topic_score_gemma":0.001467835,"domain_scores_codex":[0.999983,0.000002725664,9.894634e-7,0.000003125511,0.000003912227,0.000006347708],"domain_scores_gemma":[0.9999821,0.000002528313,0.000007169878,0.000001747777,0.000002049852,0.000004422566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003321266,0.00006134012,0.0002145203,0.00008285035,0.00002131514,0.00003676939,0.00001009906,0.001495871,0.9948398,0.000134423,0.00004225803,0.002728503],"study_design_scores_gemma":[0.00005598647,0.000605157,0.003850835,0.000006820809,0.00003707216,0.00009693737,0.00002360384,0.007564661,0.985936,0.0000850714,0.001729425,0.000008561046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974173,0.001009731,0.0009074543,0.00003485967,0.000008342491,0.000008471611,0.00007614445,0.0000387797,0.0004989093],"genre_scores_gemma":[0.9979062,0.0006043896,0.0009669422,0.00002211987,0.000001167417,0.000005635978,0.00008077837,0.000007548277,0.0004053464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132585,"threshold_uncertainty_score":0.002636254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578650042927352,"score_gpt":0.3308004679746454,"score_spread":0.3050139675453719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}