{"id":"W4413026881","doi":"10.21203/rs.3.rs-7115885/v1","title":"Polygenic Risk Scores for Pediatric Obsessive-Compulsive Symptoms and their Mediating Effect in Clinically Diagnosed Samples of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tourette syndrome","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; SickKids Foundation; Hospital for Sick Children; University of Calgary","funders":"National Institutes of Health; Alberta Innovates","keywords":"Psychiatry; Anxiety; Attention deficit hyperactivity disorder; Autism spectrum disorder; Psychology; Genome-wide association study; Depression (economics); Clinical psychology; Autism; Tourette syndrome; Anxiety disorder; Single-nucleotide polymorphism; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009552886,0.00129786,0.0004491953,0.001260347,0.0005530105,0.00119413,0.0008594867,0.0007637474,0.004461204],"category_scores_gemma":[0.004558482,0.000527944,0.001146548,0.001119306,0.0005420888,0.0005641155,0.001124373,0.001166886,0.000343529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004237373,"about_ca_system_score_gemma":0.0007904841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02035749,"about_ca_topic_score_gemma":0.01535717,"domain_scores_codex":[0.9988808,0.0005376406,0.00005133428,0.0002495234,0.0001028046,0.0001779709],"domain_scores_gemma":[0.9968712,0.001408437,0.0007405145,0.0003081656,0.000144294,0.0005275303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002263983,0.00008677647,0.996888,0.000004392263,0.0001796446,0.0002617243,0.0001370322,0.0001122089,0.0004829882,0.0001249377,0.0001323837,0.001363578],"study_design_scores_gemma":[0.000009187295,0.00006291803,0.9987264,0.000005281448,0.00007240453,0.0002592758,0.0002282991,0.0004020373,0.00007756562,0.00009296137,0.00005885257,0.000004739617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988769,0.0001061135,0.0001322347,0.00008041323,0.000008979007,0.000003882266,0.0002972827,0.00001362149,0.0004806695],"genre_scores_gemma":[0.9987636,0.00007640277,0.0001598362,0.00001329381,0.00001183713,0.000008554824,0.0003990887,0.000009864765,0.00055774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02035749,"threshold_uncertainty_score":0.04047799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950720544700126,"score_gpt":0.3603687578692195,"score_spread":0.3408615524222182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}