{"id":"W4413029698","doi":"10.1186/s12985-025-02906-4","title":"Methylprednisolone pulse therapy compared with intravenous dexamethasone for severe COVID-19 patients: a randomized clinical trial","year":2025,"lang":"en","type":"article","venue":"Virology Journal","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Dexamethasone; Methylprednisolone; Coronavirus disease 2019 (COVID-19); Randomized controlled trial; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Rescue therapy; Medicine; Virology; Corticosteroid; Biology; Internal medicine; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01194702,0.000333894,0.002638244,0.0003976239,0.0004820246,0.00004803962,0.0003661917,0.000389643,0.0003137123],"category_scores_gemma":[0.1615233,0.0002069185,0.000823328,0.0003750812,0.001533687,0.00007356168,0.0001405325,0.001555257,0.00001041782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854793,"about_ca_system_score_gemma":0.002526779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004679026,"about_ca_topic_score_gemma":0.00002250668,"domain_scores_codex":[0.9933292,0.003012529,0.001792014,0.0005980199,0.0005381904,0.0007300535],"domain_scores_gemma":[0.9216888,0.07508516,0.0007602145,0.0006043222,0.0009235591,0.0009379294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9506211,0.002466946,0.0108928,0.00009334663,0.003364382,0.00009355517,0.0002182022,0.00008122101,0.00004166643,0.0001031157,0.004574154,0.0274495],"study_design_scores_gemma":[0.9490173,0.01301065,0.007371372,0.00006273947,0.0008175751,0.00003317568,0.00005575247,0.0007698215,0.0000136544,0.005133894,0.02351926,0.000194741],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8048318,0.001225463,0.1340227,0.05153695,0.001176103,0.006832662,0.0000406633,0.00008950424,0.0002440987],"genre_scores_gemma":[0.950525,0.004862001,0.007047769,0.03515326,0.0009333442,0.0005864895,0.00003664388,0.00004352327,0.0008119954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1495763,"threshold_uncertainty_score":0.8455395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09690361399764713,"score_gpt":0.4824975072563189,"score_spread":0.3855938932586718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}