{"id":"W4413032352","doi":"10.20944/preprints202508.0032.v1","title":"Cardiac Cell and Animal Models for Duchenne Muscular Dystrophy in the Era of Gene Therapy and Precision Medicine","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; Muscular Dystrophy Canada; University of Alberta; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute; Alberta Innovates; Heart and Stroke Foundation of Canada; U.S. Department of Defense","keywords":"Duchenne muscular dystrophy; Genetic enhancement; Muscular dystrophy; Precision medicine; Medicine; Internal medicine; Cardiology; Gene; Bioinformatics; Biology; Genetics; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002834938,0.0006924543,0.0009851035,0.00183194,0.0004576576,0.001614936,0.0007592935,0.001788202,0.003287555],"category_scores_gemma":[0.001082364,0.0003638421,0.0008362417,0.0008159171,0.001090323,0.001186316,0.000956956,0.003133619,0.00172925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007604028,"about_ca_system_score_gemma":0.0008124289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005632883,"about_ca_topic_score_gemma":0.0008065827,"domain_scores_codex":[0.998753,0.0003496487,0.0001287912,0.0001463767,0.0005543396,0.00006780804],"domain_scores_gemma":[0.9992705,0.0002969792,0.00009386605,0.0001230661,0.000131406,0.00008421973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007084436,0.0002389715,0.001186769,0.005542941,0.0002594855,0.001156757,0.0004612558,0.001229774,0.7531157,0.07262162,0.02173506,0.1417432],"study_design_scores_gemma":[0.0001533557,0.001625287,0.004490964,0.002326904,0.0006173095,0.005306988,0.0002568782,0.001863091,0.2458138,0.02161906,0.7157745,0.0001517825],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08486845,0.5313456,0.2865474,0.01439115,0.006548061,0.0009917327,0.009263613,0.003835513,0.06220854],"genre_scores_gemma":[0.2297602,0.5136031,0.1987124,0.005940799,0.00170302,0.001982194,0.01321649,0.001115703,0.03396608],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003287555,"threshold_uncertainty_score":0.01499271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07174571046101658,"score_gpt":0.3376672936228596,"score_spread":0.265921583161843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}