{"id":"W4413032847","doi":"10.1038/s41598-025-13635-7","title":"Giardia duodenalis stabilizes HIF-1α and induces glycolytic alterations in intestinal epithelial cells","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; International Microbiome Centre, University of Calgary; Canterbury Medical Research Foundation","keywords":"Biology; Intestinal epithelium; Giardia; Hypoxia (environmental); Glycolysis; Downregulation and upregulation; Intestinal mucosa; Mucin; Epithelium; Microbiology; Cell biology; Metabolism; Chemistry; Biochemistry; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634711,0.0002645522,0.00027901,0.0001519646,0.0001684922,0.0002186645,0.0000909825,0.0003085354,0.0006758299],"category_scores_gemma":[0.0001302861,0.0001812348,0.0002455708,0.0001264322,0.000210317,0.0001032365,0.0002554342,0.000464449,0.0001684448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521985,"about_ca_system_score_gemma":0.0001191574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000874789,"about_ca_topic_score_gemma":0.001045855,"domain_scores_codex":[0.9998405,0.00003817726,0.00001237991,0.00002479385,0.00002695744,0.00005717034],"domain_scores_gemma":[0.999933,0.00001099742,0.00001748656,0.00001279607,0.000008720059,0.00001703251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009702592,0.00001475784,0.0001254576,0.00002484097,0.000003538996,0.00003788189,0.00001476439,0.00001530409,0.9992666,0.000009257664,0.00003573816,0.0003547403],"study_design_scores_gemma":[0.00003847678,0.0008919301,0.03454449,0.00001718725,0.00002558051,0.0003529111,0.0001233844,0.0006768846,0.9597164,0.00005163533,0.003554163,0.000006899638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964535,0.001705124,0.0006744688,0.0001723675,0.00004942016,0.00002235177,0.0001770059,0.00005044836,0.0006954073],"genre_scores_gemma":[0.9964917,0.0008975046,0.0008535706,0.0001522799,0.00001943536,0.00002811103,0.0004510591,0.000009428929,0.001096836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000874789,"threshold_uncertainty_score":0.002260864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009578960092633199,"score_gpt":0.2593705022469097,"score_spread":0.2497915421542765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}