{"id":"W4413037173","doi":"10.14814/phy2.70453","title":"Elimination of hepatocyte‐derived <scp>DPP4</scp> downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice","year":2025,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; University of Ottawa Heart Institute Foundation; Government of Canada; Institute of Nutrition, Metabolism and Diabetes; Heart and Stroke Foundation of Canada","keywords":"Immune system; Cardiac function curve; Hepatocyte; Function (biology); Cell biology; Gene; Chemistry; Medicine; Immunology; Pharmacology; Internal medicine; Biology; Heart failure; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004109911,0.000208893,0.0007596113,0.0002098133,0.00008269173,0.00001696521,0.00003532104,0.0002159296,0.0000649862],"category_scores_gemma":[0.0004972539,0.0001449322,0.000313716,0.0004109276,0.0001555409,0.00008360006,0.0000785766,0.0001441698,0.000004356537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006119011,"about_ca_system_score_gemma":0.00005135871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001318949,"about_ca_topic_score_gemma":0.00000525419,"domain_scores_codex":[0.9981263,0.0001932326,0.000735906,0.0004822194,0.0002273501,0.0002349797],"domain_scores_gemma":[0.9989171,0.0002129584,0.0003095507,0.0002942872,0.0001825651,0.00008354259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006871908,0.0001372475,0.02087981,0.0001057131,0.0002070285,0.00007208659,0.00008411925,0.00004494244,0.9771441,0.00004167837,0.0001656505,0.001048955],"study_design_scores_gemma":[0.000310463,0.00008909941,0.5415208,0.0001705473,0.0001782598,0.000009966903,0.0002991754,0.0001534401,0.4567827,0.0003374297,0.0000916164,0.00005644638],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972339,0.0008935828,0.00001882645,0.0001637632,0.0001409536,0.0005198891,0.00001962513,0.00005982651,0.0009496707],"genre_scores_gemma":[0.9961714,0.0004409279,0.00007776662,0.0001565716,0.0000498376,0.00008921557,0.0002215815,0.000009946207,0.0027828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.520641,"threshold_uncertainty_score":0.5910165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093094216811172,"score_gpt":0.2483571585419284,"score_spread":0.2374262163738167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}