{"id":"W4413039272","doi":"10.1002/ana.70020","title":"Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Manitoba Health; Nova Scotia Health Authority; Dalhousie University; University of Manitoba","funders":"Congressionally Directed Medical Research Programs; Uppsala Multidisciplinary Center for Advanced Computational Science; HORIZON EUROPE Framework Programme; Alliance de recherche numérique du Canada; Uppsala Universitet; National Institute of Mental Health; Vetenskapsrådet; U.S. Department of Defense; European Commission; Multiple Sclerosis Society; University of Manitoba; Canadian Institutes of Health Research; Genome Canada","keywords":"Multiple sclerosis; Depression (economics); Disease; Medicine; Psychiatry; Psychology; Physical medicine and rehabilitation; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004327097,0.0005634551,0.00103616,0.0007652339,0.0002866149,0.000958511,0.0004647246,0.0006150966,0.0009485404],"category_scores_gemma":[0.005997478,0.0003393154,0.003814628,0.001258432,0.0004371373,0.0003462584,0.0006695352,0.0006282075,0.00006261238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003121232,"about_ca_system_score_gemma":0.0003076615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005470779,"about_ca_topic_score_gemma":0.004794753,"domain_scores_codex":[0.9980704,0.001149987,0.0001637379,0.000392384,0.000147456,0.00007611514],"domain_scores_gemma":[0.995965,0.002157535,0.001148116,0.0004657219,0.0001334239,0.000130154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002661516,0.00005414182,0.9218201,0.0007546135,0.05223037,0.0001796,0.00007084838,0.00233307,0.00067247,0.0002391112,0.0002667061,0.0187175],"study_design_scores_gemma":[0.0002337696,0.0004611196,0.9657642,0.000313934,0.02688066,0.0003860231,0.00004300586,0.004201047,0.0002169838,0.0008120296,0.0006710079,0.00001616689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9305956,0.06525633,0.001860524,0.0006324878,0.0000736432,0.00003571045,0.0008813306,0.00003263459,0.0006316876],"genre_scores_gemma":[0.9955776,0.003650322,0.0003238673,0.00006634859,0.00003722912,0.00001049634,0.0002459419,0.000002778218,0.00008544634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005470779,"threshold_uncertainty_score":0.02288419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1424295457635396,"score_gpt":0.3730518235874487,"score_spread":0.2306222778239091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}