{"id":"W4413043497","doi":"10.1073/pnas.2500006122","title":"Discovery and development of an oral analgesic targeting the α2B adrenoceptor","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"Japan Science and Technology Agency; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Analgesic; Medicine; Analgesic agents; Pharmacology; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652289,0.0003232481,0.0003248401,0.0003626983,0.000147491,0.0002985362,0.0003225035,0.0002845657,0.001001172],"category_scores_gemma":[0.00008185077,0.0001442775,0.0002681662,0.0001596229,0.0002136599,0.0002649449,0.0001937131,0.0009165957,0.0002922849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060976,"about_ca_system_score_gemma":0.0003756058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005642881,"about_ca_topic_score_gemma":0.001363657,"domain_scores_codex":[0.9999441,0.00000715939,0.000004322661,0.00001025428,0.00001811416,0.00001602506],"domain_scores_gemma":[0.9999659,0.000002452463,0.000008782406,0.000003149869,0.000007607174,0.00001209705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894224,0.000200177,0.0002121079,0.0002627501,0.00002000075,0.0001950222,0.00002687568,0.0001182883,0.9693308,0.0007999652,0.0002148084,0.02842988],"study_design_scores_gemma":[0.0003674958,0.008576688,0.007289229,0.00009796487,0.0001566246,0.001696638,0.00006320517,0.00125313,0.935476,0.0003001819,0.04468288,0.00004013398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8792052,0.07105312,0.03224169,0.0012737,0.000277512,0.0006565149,0.0007578412,0.000209246,0.01432516],"genre_scores_gemma":[0.907389,0.05651931,0.02497437,0.0006440978,0.0001425128,0.0002201552,0.001052004,0.00002128223,0.009037366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001172,"threshold_uncertainty_score":0.003349304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691661114891135,"score_gpt":0.3266507650170466,"score_spread":0.2897341538681352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}