{"id":"W4413046073","doi":"10.1016/j.eclinm.2025.103413","title":"Switch to mania after acute antidepressant treatment for bipolar depression: a systematic review and network meta-analysis of randomised controlled trials","year":2025,"lang":"en","type":"review","venue":"EClinicalMedicine","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"European Social Fund; Instituto de Salud Carlos III; European Commission; European Regional Development Fund; Horizon 2020 Framework Programme; Departament de Salut, Generalitat de Catalunya; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Generalitat de Catalunya; Ministerio de Ciencia e Innovación; Centres de Recerca de Catalunya; Milken Family Foundation; Fundació Clinic per la Recerca Biomèdica","keywords":"Medicine; Meta-analysis; Antidepressant; Depression (economics); Mania; Bipolar disorder; Psychiatry; Randomized controlled trial; Internal medicine; Mood; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad"],"consensus_categories":["metaepi_broad"],"category_scores_codex":[0.008703315,0.001199019,0.08251027,0.0007110309,0.00008055058,0.0000207905,0.0002524493,0.0004883864,0.0005077354],"category_scores_gemma":[0.008380654,0.0005162467,0.01905547,0.001328821,0.00008594565,0.00002710607,0.0001189489,0.0002759801,0.000009383196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009074082,"about_ca_system_score_gemma":0.0003975587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002411833,"about_ca_topic_score_gemma":0.00003311451,"domain_scores_codex":[0.9870772,0.002519349,0.008176749,0.001174643,0.0005588323,0.000493253],"domain_scores_gemma":[0.973291,0.02105795,0.002993946,0.001842671,0.0003209063,0.0004935729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00326659,0.0003912371,0.00003701611,0.4170904,0.5654595,0.00002581009,0.00001184398,3.063023e-7,3.533736e-8,0.0000054055,0.0004499987,0.01326188],"study_design_scores_gemma":[0.03980824,0.0008654385,0.0000171481,0.1658696,0.7368468,0.00002322651,0.000002207541,0.000007844568,1.62278e-7,0.000006939445,0.05630994,0.0002424444],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[3.784653e-7,0.9458053,0.000674955,0.0008880235,0.000160366,0.05168616,0.0006710645,0.00004110489,0.00007269224],"genre_scores_gemma":[0.00001908185,0.965615,0.0009193015,0.001126104,0.0001984026,0.02935262,0.0006031977,0.0000664985,0.00209979],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2512208,"threshold_uncertainty_score":0.9999722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1460304331457872,"score_gpt":0.4547442006138098,"score_spread":0.3087137674680225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}