{"id":"W4413048510","doi":"10.1167/iovs.66.11.18","title":"Matrine Reduces Intraocular Pressure in Corticosteroid-Induced Ocular Hypertensive Mouse Eyes","year":2025,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Children's Health Research Institute; National Eye Institute; American Glaucoma Society; U.S. Department of Veterans Affairs","keywords":"Intraocular pressure; Matrine; Corticosteroid; Ophthalmology; Medicine; Ocular hypertension; Elevated intraocular pressure; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005023265,0.0003153885,0.000362228,0.0003050023,0.0002348031,0.00006682942,0.0007569027,0.0003072789,0.00001466198],"category_scores_gemma":[0.001183969,0.0002878191,0.00007898893,0.00114067,0.002634726,0.00004074172,0.0005765323,0.0004013804,0.00001080604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007704079,"about_ca_system_score_gemma":0.0005275183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001542365,"about_ca_topic_score_gemma":0.00001353631,"domain_scores_codex":[0.9974271,0.0002690686,0.0003631444,0.001036364,0.0003046993,0.0005996139],"domain_scores_gemma":[0.9987543,0.00005380608,0.0001537343,0.0004081845,0.000447328,0.0001826496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008209953,0.0001024614,0.0138294,0.00001329154,0.00005875116,0.00007838114,0.00007606802,0.0000236679,0.9853659,0.00009186604,0.00008262962,0.0001955018],"study_design_scores_gemma":[0.0004694611,0.0005332445,0.04330155,0.00003650899,0.00002551018,0.0001031458,0.0001692352,0.0001711465,0.9539366,0.0007075265,0.0002681074,0.0002779216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965767,0.001066401,0.000005462665,0.0006888645,0.0003238991,0.000422593,0.000009030936,0.00002200713,0.000885],"genre_scores_gemma":[0.9980399,0.00001711571,0.0005585232,0.0006984291,0.00006273274,0.00004938915,0.00001973072,0.00001598939,0.0005381924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03142924,"threshold_uncertainty_score":0.9999574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199340346001213,"score_gpt":0.3255939506512248,"score_spread":0.3036005471912127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}