{"id":"W4413050116","doi":"10.1002/mds.30325","title":"Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space ( <scp>DTI</scp> ‐ <scp>ALPS)</scp> , is Linked to Poor Cognitive Outcomes in Parkinson's Disease","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Hjärnfonden; European Commission; University College London; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Stiftelsen för Gamla Tjänarinnor; Familjen Erling-Perssons Stiftelse; Biogen; Eli Lilly and Company; HORIZON EUROPE Framework Programme; Wellcome Trust; Nvidia; Alzheimer's Drug Discovery Foundation; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Alzheimer's Association","keywords":"Diffusion MRI; Perivascular space; Glymphatic system; Parkinson's disease; Neuroscience; Cognition; Diffusion; Psychology; Disease; Medicine; Pathology; Physics; Magnetic resonance imaging; Cerebrospinal fluid; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005488958,0.0004151575,0.0002075357,0.0008250692,0.0002079557,0.0005322088,0.0001667006,0.0002369803,0.001178026],"category_scores_gemma":[0.001166257,0.0001180771,0.0002420078,0.0004525779,0.0004171334,0.0004218384,0.0003465746,0.000273355,0.0001264875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002664764,"about_ca_system_score_gemma":0.0001975258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975481,"about_ca_topic_score_gemma":0.00240625,"domain_scores_codex":[0.999892,0.00002281003,0.00001917821,0.00002849246,0.00002372612,0.0000138341],"domain_scores_gemma":[0.9991111,0.00007773266,0.0006027191,0.00004412092,0.00008128666,0.00008307911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001265594,0.00006594395,0.9616933,0.0001064702,0.0003689726,0.0003662577,0.0002617396,0.0005246929,0.02349986,0.0001498658,0.0001911086,0.01150624],"study_design_scores_gemma":[0.00001537206,0.0002616179,0.9938651,0.00001156828,0.00005948651,0.001094243,0.00009969244,0.001072252,0.003183203,0.0001788616,0.0001502627,0.000008411345],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988263,0.0002130451,0.0004722498,0.00001927043,0.0000020441,0.000008427109,0.0001689078,0.000007505526,0.0002822158],"genre_scores_gemma":[0.9990331,0.0001097638,0.0005816733,0.000006064062,0.000003696607,0.000006024301,0.0001508687,0.000002725837,0.0001061228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975481,"threshold_uncertainty_score":0.00394088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528559549505867,"score_gpt":0.2654834274210864,"score_spread":0.2501978319260277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}