{"id":"W4413054552","doi":"10.1126/sciadv.ady8566","title":"Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Islet; Pancreatic islets; Endocrinology; Internal medicine; Enteroendocrine cell; Transplantation; Secretion; Heparan sulfate; Cell biology; Inflammation; Insulin; Signal transduction; Biology; Chemistry; Medicine; Endocrine system; Heparin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117319,0.0003380434,0.0002415935,0.0001524072,0.00008053196,0.0002551628,0.0001293012,0.0001485488,0.0007315117],"category_scores_gemma":[0.00005889353,0.00007649983,0.000161723,0.00009979204,0.0001803689,0.000207336,0.0001481525,0.0007056445,0.0001190682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235263,"about_ca_system_score_gemma":0.0001348133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009188439,"about_ca_topic_score_gemma":0.0001832802,"domain_scores_codex":[0.9998966,0.00001694635,0.000009359514,0.00001936961,0.00002549773,0.00003212092],"domain_scores_gemma":[0.9999392,0.00001121808,0.00001768539,0.000005616276,0.000003095745,0.00002324368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002215889,0.0001182767,0.0001322178,0.00001630967,0.000003721449,0.00002652058,0.00001236263,0.00005610104,0.9981542,0.00005024666,0.0000148968,0.001193614],"study_design_scores_gemma":[0.00002035121,0.0006642443,0.002279232,0.000003240166,0.00001412082,0.000087735,0.0000255348,0.0007784107,0.9956226,0.00004121102,0.0004614419,0.000001931001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983966,0.0004089694,0.0006501022,0.00002717267,0.00002501837,0.000007629895,0.0000327675,0.00001803945,0.00043369],"genre_scores_gemma":[0.9976786,0.0004310369,0.0007797403,0.00002799391,0.00001457512,0.00001300895,0.00007110407,0.000008164029,0.000975664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007315117,"threshold_uncertainty_score":0.002447128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131678611950961,"score_gpt":0.2837464973325234,"score_spread":0.2724297112130138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}