{"id":"W4413056070","doi":"10.1371/journal.ppat.1013291","title":"Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Julius-Maximilians-Universität Würzburg; Deutsche Forschungsgemeinschaft; Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg; Deutscher Akademischer Austauschdienst","keywords":"Staphylococcus aureus; Intracellular; Biology; Mutant; Intracellular parasite; Microbiology; Cell biology; Repressor; Bacteria; Amino acid; Gene; Biochemistry; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604468,0.0002783423,0.0002578348,0.0001577897,0.0001024057,0.0002721362,0.0003970672,0.0003486759,0.0009188832],"category_scores_gemma":[0.0001534718,0.0001532909,0.0002120565,0.0001035282,0.0002539871,0.0001279227,0.0003381408,0.0005319255,0.0004132219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003385352,"about_ca_system_score_gemma":0.0003105297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000912882,"about_ca_topic_score_gemma":0.00115831,"domain_scores_codex":[0.9997922,0.0000353172,0.00002410726,0.00003318414,0.00005490846,0.00006030613],"domain_scores_gemma":[0.9997486,0.00006100747,0.00006282405,0.00003976383,0.00002175861,0.00006590696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006074308,0.00001913779,0.00006579328,0.00001092501,0.000001269468,0.00002750648,0.000008179602,0.00003269455,0.999333,0.0000668918,0.00001830811,0.0003555102],"study_design_scores_gemma":[0.00001969837,0.0002309297,0.002845636,0.000006962979,0.000005224259,0.000143565,0.00003146548,0.001522702,0.9936323,0.00005871712,0.00149854,0.000004327537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956102,0.0005129623,0.002340773,0.0001330689,0.00002647934,0.00002028765,0.0003046927,0.0001225087,0.0009290944],"genre_scores_gemma":[0.9953645,0.0002830458,0.001575125,0.00004965877,0.000004949322,0.00003249364,0.0003120831,0.00004538248,0.002332647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009188832,"threshold_uncertainty_score":0.00307399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008517407415552968,"score_gpt":0.2190111510600378,"score_spread":0.2104937436444848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}