{"id":"W4413057578","doi":"10.21203/rs.3.rs-7013135/v1","title":"Somatic DICER1 pathogenic variants in a well-differentiated fetal lung adenocarcinoma diagnosed in a man with familial adenomatous polyposis","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Congenital Diaphragmatic Hernia Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital; University of Toronto; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Merck Canada","keywords":"Familial adenomatous polyposis; Biology; Germline; Germline mutation; Genetics; Medicine; Gene; Mutation; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482645,0.0008178564,0.0004260563,0.001640085,0.001045061,0.000504492,0.0004177319,0.001974896,0.002685148],"category_scores_gemma":[0.001284613,0.0004226376,0.0005385076,0.00056967,0.0006874147,0.0003612965,0.0004863678,0.0007359332,0.0004825603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003978247,"about_ca_system_score_gemma":0.0002406674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002818368,"about_ca_topic_score_gemma":0.001934225,"domain_scores_codex":[0.9997868,0.00002207956,0.00002273599,0.00008150625,0.00003629554,0.00005054288],"domain_scores_gemma":[0.99941,0.0002302834,0.00007138755,0.00003469854,0.00004247876,0.0002110479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001806593,0.00002821177,0.0332646,0.00002772131,0.00001921903,0.957543,0.0004259595,0.0001469131,0.00657403,0.0002310987,0.000283994,0.001274643],"study_design_scores_gemma":[0.00002401898,0.0002132093,0.0750588,0.00001825279,0.00006814396,0.9191013,0.0003689595,0.0005969073,0.003324452,0.0002683384,0.0009329514,0.0000246633],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952887,0.0006515964,0.0007052993,0.0005821054,0.00007060225,0.00002987711,0.0003669588,0.00004118522,0.002263641],"genre_scores_gemma":[0.9986919,0.0001546353,0.0003699033,0.00008137181,0.0000691947,0.000002476497,0.00007353377,0.00001056739,0.0005464402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002818368,"threshold_uncertainty_score":0.008982778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03234628357609864,"score_gpt":0.3464506800468717,"score_spread":0.314104396470773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}