{"id":"W4413094517","doi":"10.1111/febs.70213","title":"Defining the interactome of the pancreas‐specific <scp>SPCA2</scp>  isoform ( <scp>SPCA2C</scp> ) identifies unique links to store‐operated Ca <sup>2+</sup> entry","year":2025,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Children’s Health Research Institute; Western University","funders":"Children's Health Foundation; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"ORAI1; STIM1; Cell biology; Calcium signaling; Biology; Interactome; Endoplasmic reticulum; Calcium-binding protein; Syntaxin; Calmodulin; HEK 293 cells; SERCA; Signal transduction; Exocytosis; Biochemistry; Chemistry; Calcium; Secretion; ATPase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477829,0.0005087883,0.0005160903,0.001167288,0.000636435,0.0005663785,0.0002205021,0.0005553365,0.002422367],"category_scores_gemma":[0.0003254101,0.0002002087,0.0006515933,0.001019464,0.0002274472,0.0004274941,0.0004789711,0.0005363227,0.0007509327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005907026,"about_ca_system_score_gemma":0.0003953893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002070981,"about_ca_topic_score_gemma":0.003916477,"domain_scores_codex":[0.9997379,0.00001642542,0.0000147699,0.000100384,0.00008738689,0.00004314993],"domain_scores_gemma":[0.9998276,0.00003223697,0.00005056452,0.00001391624,0.00003578142,0.0000399225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003225128,0.00002664582,0.007646416,0.0002011456,0.00008988721,0.0003559977,0.00005357709,0.0002473621,0.985664,0.0003526078,0.0007294622,0.004310352],"study_design_scores_gemma":[0.00006721807,0.000260616,0.4338786,0.00008639675,0.0004178027,0.004620861,0.0003760789,0.02428907,0.4996324,0.001114992,0.0351841,0.00007189794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768795,0.003664016,0.008147792,0.0004508282,0.00004752673,0.00004533709,0.00765354,0.0001905331,0.002920936],"genre_scores_gemma":[0.9578175,0.002287892,0.01450521,0.0004997656,0.00005367838,0.0001887802,0.01959723,0.00009765297,0.004952214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422367,"threshold_uncertainty_score":0.008103609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439658761426164,"score_gpt":0.2581615686005432,"score_spread":0.2437649809862815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}