{"id":"W4413094517","doi":"10.1111/febs.70213","title":"Defining the interactome of the pancreas‐specific <scp>SPCA2</scp>  isoform ( <scp>SPCA2C</scp> ) identifies unique links to store‐operated Ca <sup>2+</sup> entry","year":2025,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Children’s Health Research Institute; Western University","funders":"Children's Health Foundation; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"ORAI1; STIM1; Cell biology; Calcium signaling; Biology; Interactome; Endoplasmic reticulum; Calcium-binding protein; Syntaxin; Calmodulin; HEK 293 cells; SERCA; Signal transduction; Exocytosis; Biochemistry; Chemistry; Calcium; Secretion; ATPase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001099197,0.0004503478,0.0005280036,0.0004419348,0.001325487,0.0006985705,0.00171097,0.000352164,0.0001412631],"category_scores_gemma":[0.003401006,0.0002606613,0.0004198802,0.001566289,0.0003240381,0.0004739645,0.0005770636,0.002397408,0.0001973001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182278,"about_ca_system_score_gemma":0.0003721547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007604553,"about_ca_topic_score_gemma":0.00002206464,"domain_scores_codex":[0.9960548,0.0006769554,0.000990691,0.0005497937,0.0008412755,0.0008864347],"domain_scores_gemma":[0.9964551,0.001820082,0.0005018785,0.0005649935,0.0003816469,0.0002763447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001163681,0.0007546623,0.006354891,0.0002339331,0.0003818042,0.0002093157,0.06455491,0.0271411,0.2451272,0.01103953,0.6370536,0.007032697],"study_design_scores_gemma":[0.001145719,0.0002289519,0.003659154,0.001124153,0.00009252174,0.0006743524,0.01644737,0.003299743,0.6545676,0.001418086,0.3171645,0.0001779133],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846559,0.001083998,0.0005420524,0.001503787,0.004715336,0.0004756332,0.00006614734,0.00007774131,0.006879463],"genre_scores_gemma":[0.9769811,0.001013077,0.00008360951,0.002323655,0.0005649048,0.00002778645,0.000005076401,0.0000556901,0.01894513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4094404,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439658761426164,"score_gpt":0.2581615686005432,"score_spread":0.2437649809862815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}