{"id":"W4413095698","doi":"10.1016/j.joen.2025.07.021","title":"Cellular Crosstalk Between Periodontal Ligament Fibroblasts and Macrophages: Insights from 2D and 3D Culture Systems in External Inflammatory Root Resorption","year":2025,"lang":"en","type":"review","venue":"Journal of Endodontics","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; American Association of Endodontists Foundation","keywords":"Periodontal fiber; Cementum; Cell biology; Periodontitis; Crosstalk; Inflammation; Immune system; Immunology; Resorption; Periodontium; Macrophage; Proinflammatory cytokine; Biology; Chemistry; Pathology; Dentin; Medicine; In vitro; Dentistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004885842,0.0005448178,0.002405427,0.0005741159,0.0001582736,0.000524092,0.0004416929,0.0009852734,0.00003560365],"category_scores_gemma":[0.0001540852,0.000425529,0.0003771286,0.0002019672,0.000241973,0.0002936764,0.0003612766,0.00185961,0.00001908929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852241,"about_ca_system_score_gemma":0.000331766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001409249,"about_ca_topic_score_gemma":0.0002987862,"domain_scores_codex":[0.9962556,0.0007717047,0.001736563,0.0004527245,0.0003877447,0.0003956101],"domain_scores_gemma":[0.9978116,0.0003804287,0.001100966,0.000306626,0.0001800818,0.0002203082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001047433,0.0007254342,0.1384359,0.1531372,0.005110083,0.03491912,0.005640514,0.00005298083,0.01506119,0.0003095776,0.005182438,0.6403781],"study_design_scores_gemma":[0.002588202,0.0004861334,0.01277109,0.1013187,0.001108502,0.00166086,0.0002723564,0.00001462121,0.0001702313,0.00008826877,0.8786815,0.0008395561],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2204581,0.7778255,0.00009352076,0.000004383604,0.0008561679,0.0004231879,0.000287232,0.000008948654,0.00004292076],"genre_scores_gemma":[0.02085391,0.976422,0.0003508918,0.000005264495,0.0009533718,0.00001125012,0.00007511086,0.00004518399,0.001283053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8734991,"threshold_uncertainty_score":0.9998196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100867913548342,"score_gpt":0.3134215646226356,"score_spread":0.2924128854871522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}