{"id":"W4413099684","doi":"10.1002/bies.70054","title":"Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases","year":2025,"lang":"en","type":"review","venue":"BioEssays","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; McMaster Institute for Research on Aging, McMaster University","keywords":"Ribosome biogenesis; Translation (biology); Ribosome; Organelle; Biology; Cell biology; Ribosome profiling; Organelle biogenesis; Biogenesis; Computational biology; Genetics; Messenger RNA; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002343059,0.0003819419,0.0007928689,0.0001119321,0.0001505149,0.00005018878,0.0001929229,0.0005522055,0.00002467816],"category_scores_gemma":[0.0001981324,0.0003331066,0.0003254889,0.0001814972,0.00006176862,0.000004842675,0.0001138318,0.000128089,0.00001575897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002292777,"about_ca_system_score_gemma":0.0002210699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001799481,"about_ca_topic_score_gemma":0.000006493911,"domain_scores_codex":[0.9982635,0.0002991534,0.0004130571,0.0006701511,0.0001276447,0.0002265183],"domain_scores_gemma":[0.9990653,0.0001452988,0.000199414,0.000412372,0.00006732598,0.0001102734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001459456,0.00002792418,0.00008324243,0.005065042,0.0002305686,0.000001948226,0.000008846347,1.057017e-7,0.000465215,0.00006114667,0.0004050365,0.9936363],"study_design_scores_gemma":[0.0002473047,0.000138482,0.0001629595,0.00255408,0.001241359,0.000008738998,0.000005532548,3.820204e-7,0.0007923529,0.0006375123,0.9937263,0.0004849843],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001120069,0.9929765,0.004670753,0.0000304052,0.0002155269,0.0007974874,0.0005719143,0.00003409385,0.0005912611],"genre_scores_gemma":[0.001588285,0.99564,0.0002251885,0.00002974174,0.0005348683,0.0001394594,0.001310807,0.00004456484,0.0004870326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9933213,"threshold_uncertainty_score":0.9999121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04787355832445284,"score_gpt":0.3196180324033717,"score_spread":0.2717444740789188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}