{"id":"W4413105905","doi":"10.1093/noajnl/vdaf123.131","title":"TRLS-08 DECODING THE GENE EXPRESSION SIGNATURE OF EARLY AND LATE BREAST CANCER BRAIN METASTASES IN PAIR-MATCHED PATIENT SAMPLES: AN INDIVIDUAL PATIENT DATA META-ANALYSIS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Oncology; Meta-analysis; Brain metastasis; Breast cancer; Medicine; Cohort; Internal medicine; Gene signature; Hazard ratio; Cancer; Metastasis; Bioinformatics; Gene; Biology; Gene expression; Genetics; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0146331,0.001664578,0.008928021,0.003665515,0.0006233744,0.003030854,0.001877105,0.001628525,0.004964661],"category_scores_gemma":[0.02371699,0.000986581,0.03275603,0.004975487,0.0004495273,0.001161311,0.001766613,0.002087392,0.0007664122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009300413,"about_ca_system_score_gemma":0.001439165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00446859,"about_ca_topic_score_gemma":0.00758147,"domain_scores_codex":[0.9866435,0.007634139,0.001875174,0.002338228,0.001113551,0.0003953361],"domain_scores_gemma":[0.9853512,0.01035515,0.001366389,0.001764181,0.0008437503,0.0003193436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00497233,0.0000315518,0.03414761,0.02340573,0.9210273,0.0001750598,0.0000574815,0.001604446,0.001271113,0.0002239145,0.002523316,0.01056015],"study_design_scores_gemma":[0.001140225,0.0004154654,0.02698268,0.001698777,0.9610038,0.000231872,0.00006972333,0.001659676,0.0005566423,0.0008067206,0.005380423,0.00005404135],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1155499,0.8168033,0.0197053,0.002841522,0.001381961,0.0007072497,0.03946095,0.0005682458,0.002981743],"genre_scores_gemma":[0.9312882,0.04026669,0.008567449,0.002206463,0.0005083572,0.001377285,0.01377527,0.0003377049,0.001672559],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0146331,"threshold_uncertainty_score":0.07738817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04014349234761541,"score_gpt":0.3204091717386174,"score_spread":0.280265679391002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}