{"id":"W4413105945","doi":"10.1093/noajnl/vdaf123.081","title":"OGCT-06 EFFICACY OF IMMUNOTHERAPY REGIMENS WITHOUT BLOOD-BRAIN BARRIER OPENING (BBBO) IN PATIENTS WITH BRAIN METASTASES (BM) FROM NON-SMALL CELL LUNG CANCER (NSCLC)","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Brain metastasis; Lung cancer; Chemotherapy; Internal medicine; Oncology; Metastasis; Phases of clinical research; Immunotherapy; Cancer; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006845284,0.0004471935,0.001033321,0.0002718709,0.0001943955,0.0006012181,0.0002155475,0.0003968791,0.001835047],"category_scores_gemma":[0.0005567666,0.0001244757,0.0006761253,0.000361036,0.000329482,0.0003686158,0.0002222586,0.0008155812,0.0004414267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004650967,"about_ca_system_score_gemma":0.0005918282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025869,"about_ca_topic_score_gemma":0.001751631,"domain_scores_codex":[0.9997742,0.0001046706,0.00001827998,0.0000346894,0.0000269075,0.00004137477],"domain_scores_gemma":[0.9996487,0.00005586883,0.00006831165,0.00002748879,0.00002910539,0.0001706101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7268088,0.01065348,0.07487825,0.0007114338,0.00101869,0.0002475595,0.0001551136,0.001603253,0.03003959,0.000226418,0.004170978,0.1494865],"study_design_scores_gemma":[0.08827641,0.474378,0.411115,0.0001337726,0.001638109,0.0008792232,0.0001688362,0.002948861,0.0112047,0.0003381451,0.008847666,0.0000712559],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953772,0.001966698,0.0001067317,0.0001013428,0.00004117475,0.000144716,0.0007275846,0.00003378387,0.001500746],"genre_scores_gemma":[0.9971349,0.0004362468,0.0001617164,0.0001066655,0.00003889827,0.0001048295,0.001514382,0.0000063082,0.0004960733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835047,"threshold_uncertainty_score":0.006138861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007819070446076805,"score_gpt":0.2940588159966758,"score_spread":0.2862397455505989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}