{"id":"W4413105945","doi":"10.1093/noajnl/vdaf123.081","title":"OGCT-06 EFFICACY OF IMMUNOTHERAPY REGIMENS WITHOUT BLOOD-BRAIN BARRIER OPENING (BBBO) IN PATIENTS WITH BRAIN METASTASES (BM) FROM NON-SMALL CELL LUNG CANCER (NSCLC)","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Brain metastasis; Lung cancer; Chemotherapy; Internal medicine; Oncology; Metastasis; Phases of clinical research; Immunotherapy; Cancer; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003173676,0.0004563337,0.001176013,0.0003043065,0.0001227748,0.0000180224,0.000264798,0.0001523927,0.0002211954],"category_scores_gemma":[0.0002329129,0.0003497391,0.0001622132,0.0005123218,0.0002605499,0.0001809788,0.0001015395,0.0004421339,0.000004425112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001438527,"about_ca_system_score_gemma":0.0005699897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004691555,"about_ca_topic_score_gemma":0.0004760546,"domain_scores_codex":[0.9972482,0.000449069,0.0006726749,0.0008030742,0.0002969156,0.0005300841],"domain_scores_gemma":[0.9967348,0.00194089,0.0004238507,0.0006178184,0.000144191,0.0001384633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005695415,0.002690959,0.9350144,0.0001831823,0.001077989,0.0002764675,0.0008726016,0.0008373652,0.02918686,0.00005892999,0.001652034,0.02245375],"study_design_scores_gemma":[0.1357241,0.008973268,0.5961803,0.002426677,0.003267264,0.00001958103,0.0008644256,0.0003160244,0.1414529,0.0001582019,0.1094488,0.001168524],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852075,0.008933747,0.0003759002,0.00201311,0.000329698,0.001870623,0.0002281576,0.00004587913,0.0009954041],"genre_scores_gemma":[0.9822464,0.0006955721,0.009942939,0.005774566,0.00008375794,0.0003308911,0.0001901456,0.0000776682,0.0006580537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3388342,"threshold_uncertainty_score":0.9998955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007819070446076805,"score_gpt":0.2940588159966758,"score_spread":0.2862397455505989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}