{"id":"W4413105992","doi":"10.1093/noajnl/vdaf123.085","title":"PRCA-06 GENOME-WIDE IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES BACE1 AS A THERAPEUTIC VULNERABILITY OF LUNG CANCER BRAIN METASTASIS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Concordia University of Edmonton; University of Calgary; Hospital for Sick Children; McMaster University","funders":"","keywords":"Metastasis; Brain metastasis; CRISPR; Cancer research; In vivo; Cancer; Lung cancer; Biology; Gene; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002785513,0.0003825894,0.000410902,0.0006018594,0.0002549102,0.0004449946,0.0003109957,0.0003935458,0.002727281],"category_scores_gemma":[0.0002367142,0.0001777938,0.0003623874,0.0002527336,0.0002605869,0.0001363154,0.0003618523,0.0006783036,0.0006458046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000339798,"about_ca_system_score_gemma":0.0003230115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170658,"about_ca_topic_score_gemma":0.001890406,"domain_scores_codex":[0.9997824,0.00003009056,0.00001608247,0.00005226605,0.00008385355,0.00003524969],"domain_scores_gemma":[0.9998487,0.00004576893,0.00003575721,0.00001664545,0.00002079588,0.00003231664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004607976,0.00002794722,0.0004694173,0.00003608969,0.00001190334,0.0001290111,0.000008950937,0.000178072,0.9968772,0.0001904698,0.0001317314,0.001893072],"study_design_scores_gemma":[0.00001610616,0.0002598748,0.006262421,0.000009586749,0.00006655139,0.001042524,0.00003803668,0.004558116,0.9818313,0.0001934584,0.005709685,0.00001228728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9510973,0.002188456,0.03276112,0.0005075429,0.00007454596,0.0002014129,0.003741191,0.001347476,0.008080911],"genre_scores_gemma":[0.9855841,0.0008587767,0.006512549,0.0001308244,0.000005325176,0.00008023951,0.001822441,0.00008085604,0.004924843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002727281,"threshold_uncertainty_score":0.009123623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009614230794601651,"score_gpt":0.3169127674438326,"score_spread":0.3072985366492309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}