{"id":"W4413105992","doi":"10.1093/noajnl/vdaf123.085","title":"PRCA-06 GENOME-WIDE IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES BACE1 AS A THERAPEUTIC VULNERABILITY OF LUNG CANCER BRAIN METASTASIS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Concordia University of Edmonton; University of Calgary; Hospital for Sick Children; McMaster University","funders":"","keywords":"Metastasis; Brain metastasis; CRISPR; Cancer research; In vivo; Cancer; Lung cancer; Biology; Gene; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004203249,0.0001930185,0.0003395228,0.0001176252,0.00009047586,0.00001711991,0.0002783743,0.0002118519,0.00006439747],"category_scores_gemma":[0.0002448703,0.0001821377,0.00009903955,0.0002518776,0.0001966395,0.00002706097,0.0001499511,0.000214779,0.000001515896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000613258,"about_ca_system_score_gemma":0.000240247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008477539,"about_ca_topic_score_gemma":0.0006150802,"domain_scores_codex":[0.9985297,0.0002192758,0.0004886606,0.0003718343,0.0001043155,0.0002862157],"domain_scores_gemma":[0.9989887,0.000271899,0.0002479635,0.000346756,0.0001036689,0.00004095541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000494325,0.0001748414,0.036033,0.0002127302,0.0002235666,0.000002812776,0.0002455054,0.003988062,0.9319403,0.0005861215,0.003378966,0.02271984],"study_design_scores_gemma":[0.001830184,0.0004887207,0.0222669,0.00006846948,0.0001216634,0.000005358509,0.0004449712,0.001011529,0.6655418,0.005650406,0.3021618,0.0004082475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754901,0.007713659,0.009207193,0.003192944,0.00041219,0.0007286626,0.0000560818,0.00001743259,0.003181762],"genre_scores_gemma":[0.9937735,0.001546352,0.000385253,0.00367147,0.0000752552,0.0001192124,0.00004014773,0.00001417,0.0003746712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2987828,"threshold_uncertainty_score":0.742736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009614230794601651,"score_gpt":0.3169127674438326,"score_spread":0.3072985366492309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}