{"id":"W4413106438","doi":"10.1164/rccm.202411-2312oc","title":"Impact of Elexacaftor/Tezacaftor/Ivacaftor on Glucose Tolerance and Abnormal Glucose Metabolism: A Phase 3b, Open-Label Clinical Trial","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Vertex Pharmaceuticals","keywords":"Medicine; Impaired glucose tolerance; Ivacaftor; Glycemic; Internal medicine; Cystic fibrosis; Diabetes mellitus; Cystic fibrosis-related diabetes; Endocrinology; Type 2 diabetes; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002474217,0.001520931,0.002123838,0.0003703239,0.0004522182,0.001311057,0.0007914734,0.002109225,0.006499923],"category_scores_gemma":[0.001438607,0.0005038043,0.001831809,0.0003801606,0.001075556,0.001057366,0.0003487557,0.003442557,0.001113292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006096372,"about_ca_system_score_gemma":0.001075714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006924457,"about_ca_topic_score_gemma":0.001295038,"domain_scores_codex":[0.9993286,0.0003515627,0.00003610303,0.0001140509,0.00006399093,0.0001056761],"domain_scores_gemma":[0.9989141,0.0002493749,0.0002401765,0.00007924594,0.00009921012,0.0004179051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9391567,0.02055802,0.001482119,0.0008220758,0.001085396,0.0000859694,0.000070797,0.0003952236,0.008562036,0.0001083177,0.001521907,0.02615132],"study_design_scores_gemma":[0.8646874,0.1299758,0.002945533,0.00005859349,0.0003575252,0.00005717136,0.00002698625,0.0003900881,0.0007068439,0.0001035833,0.000675327,0.00001519284],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828039,0.006973507,0.0006914476,0.001155593,0.0003622534,0.003622873,0.001674056,0.0001590616,0.002557389],"genre_scores_gemma":[0.9861571,0.003046579,0.001614199,0.001532509,0.0003937813,0.003539788,0.0009642888,0.00003112962,0.002720502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006499923,"threshold_uncertainty_score":0.02174437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06236723984757143,"score_gpt":0.4863143428073939,"score_spread":0.4239471029598225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}