{"id":"W4413106617","doi":"10.1002/ptr.70063","title":"Coptisine Improves Liver Inflammation in Sepsis by Regulating <scp>STAT1</scp>/<scp>IRF1</scp>/<scp>GPX4</scp> Signaling‐Mediated Kupffer Cells Ferroptosis","year":2025,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Inflammation; HMGB1; Microbiology; Biology; Cell biology; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003129878,0.000879855,0.001411929,0.001741117,0.0005677352,0.0004394333,0.0008032437,0.000727672,0.0001674336],"category_scores_gemma":[0.002942222,0.0008321673,0.0004281721,0.004233236,0.0005478224,0.0005649803,0.0003051458,0.001971212,0.0002266994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001027723,"about_ca_system_score_gemma":0.0009174909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008933448,"about_ca_topic_score_gemma":0.0001581064,"domain_scores_codex":[0.9911149,0.0009815492,0.001531798,0.00165738,0.002372635,0.002341745],"domain_scores_gemma":[0.9905447,0.005864845,0.0004280261,0.001224617,0.001323173,0.0006146872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244704,0.0008417299,0.01981956,0.001005802,0.0005628804,0.00004858674,0.005605281,0.0001324405,0.8451181,0.000131781,0.1093073,0.01730206],"study_design_scores_gemma":[0.006065832,0.001184435,0.01607047,0.001281981,0.0001300625,0.000007223993,0.003959661,0.006727605,0.8450976,0.0003292323,0.1189817,0.0001641274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776474,0.009528039,0.0003107498,0.001294442,0.0003536707,0.002904248,0.0001266041,0.0003215846,0.007513267],"genre_scores_gemma":[0.9569738,0.007250892,0.001414053,0.001148783,0.0007371054,0.001215464,0.0003517069,0.0003025274,0.03060566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02309239,"threshold_uncertainty_score":0.9994129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03446921079171331,"score_gpt":0.3343793442110596,"score_spread":0.2999101334193464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}