{"id":"W4413106907","doi":"10.1073/pnas.2506281122","title":"ITAF <sub>45</sub> is a pervasive <i>trans</i> -acting factor for picornavirus Type II IRES elements","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Research Council; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Terry Fox Foundation; UK Research and Innovation; Ottawa Hospital Research Institute; McGill University","keywords":"Internal ribosome entry site; Picornavirus; Biology; Virology; Translation (biology); RNA; Virus; Ribosome; Initiation factor; Eukaryotic translation; Messenger RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773764,0.0005189063,0.0003275652,0.0002798556,0.0002916288,0.000458602,0.0001746237,0.0003043111,0.001492953],"category_scores_gemma":[0.0002452268,0.000191793,0.0005259995,0.0001382782,0.0002823804,0.0002312666,0.0003401808,0.0006702885,0.0009123311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004026493,"about_ca_system_score_gemma":0.0002281461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008646152,"about_ca_topic_score_gemma":0.0008563497,"domain_scores_codex":[0.9997181,0.0000219683,0.00002352521,0.00007890655,0.00009713867,0.00006031897],"domain_scores_gemma":[0.9998141,0.00002649829,0.00006298354,0.00002647021,0.00001963721,0.00005031351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002373275,0.00000666062,0.0004711968,0.00002086784,0.000003435476,0.00007097029,0.00001355635,0.00002214206,0.9979872,0.0001074145,0.00004828384,0.001224677],"study_design_scores_gemma":[0.000004863426,0.00008197731,0.008971315,0.00001034713,0.00001921703,0.001041225,0.00003597021,0.0006220815,0.980925,0.00006610069,0.008211867,0.000009987672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662129,0.002506629,0.02559976,0.0001590081,0.000128935,0.00005185998,0.0007940572,0.000685232,0.003861649],"genre_scores_gemma":[0.9874392,0.0005061026,0.007213928,0.000125803,0.00002436745,0.00003357516,0.001290048,0.0001579784,0.003208913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492953,"threshold_uncertainty_score":0.004994392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08236995599020207,"score_gpt":0.3879933370298101,"score_spread":0.3056233810396081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}