{"id":"W4413107492","doi":"10.1007/s11306-025-02298-0","title":"Metabolic profiling of amniotic fluid by differential 12C-/13C-isotope dansylation labeling LC-MS for application in trisomy 21 fetuses","year":2025,"lang":"en","type":"article","venue":"Metabolomics","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Science and Technology Council","keywords":"Metabolomics; Amniotic fluid; Metabolome; Fetus; Metabolite; Biomarker; Biology; Trisomy; Bioinformatics; Biochemistry; Genetics; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003445239,0.0001894133,0.0006030961,0.0002321473,0.00006284969,0.00001998708,0.0001433148,0.0001610583,0.000006779755],"category_scores_gemma":[0.0009238509,0.0001759176,0.0001193257,0.0004236777,0.00005261106,0.0000891273,0.00005771948,0.0001774287,0.000003349953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004016834,"about_ca_system_score_gemma":0.0001018629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002041526,"about_ca_topic_score_gemma":0.00002264442,"domain_scores_codex":[0.9985552,0.00005705731,0.000601288,0.0003320255,0.0001817063,0.0002726905],"domain_scores_gemma":[0.9989377,0.0003534344,0.000177653,0.0003195193,0.0001466159,0.00006505609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001303213,0.0008264692,0.1826304,0.0006678344,0.0002832129,0.000001310336,0.0002393927,0.0008423693,0.7275994,0.02612779,0.0007423693,0.05873621],"study_design_scores_gemma":[0.007378912,0.0001465765,0.04782771,0.0002689304,0.001034811,0.00000238858,0.0001609472,0.06556969,0.8659633,0.00171127,0.009597952,0.0003374821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.749931,0.004716,0.2433468,0.0002298355,0.0002079307,0.001203564,0.0001242147,0.00005805683,0.0001826531],"genre_scores_gemma":[0.9741393,0.0005611159,0.02404897,0.0001345278,0.0001107159,0.0001913936,0.0006224328,0.00002614184,0.0001653687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2242083,"threshold_uncertainty_score":0.7173713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385044809526075,"score_gpt":0.2812107058104201,"score_spread":0.2673602577151594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}