{"id":"W4413108345","doi":"10.1038/s41525-025-00518-z","title":"Rapid generation of a sdhb loss-of-function zebrafish model for secreting pheochromocytomas and paragangliomas","year":2025,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institut national de la recherche scientifique; Armand-Frappier Foundation; Cancer Research Society","keywords":"SDHB; Zebrafish; Paraganglioma; Biology; Pheochromocytoma; In vivo; Genetic model; Internal medicine; Cancer research; Endocrinology; Gene; Genetics; Medicine; Pathology; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005122575,0.000171929,0.0005670151,0.0002706836,0.00006911864,0.000002933255,0.00006500505,0.0001110531,0.00009104049],"category_scores_gemma":[0.0002507383,0.0001369992,0.00008124455,0.0002598918,0.0002187739,0.00004287825,0.00003383131,0.00010972,0.000001229335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000448925,"about_ca_system_score_gemma":0.0001850904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002744911,"about_ca_topic_score_gemma":0.00001106742,"domain_scores_codex":[0.9987067,0.00003164431,0.0005946374,0.0002890247,0.0001831067,0.0001949179],"domain_scores_gemma":[0.9990732,0.0001402882,0.0002392088,0.0002473669,0.0002047214,0.00009521387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.006462548,0.0004421771,0.004152345,0.005232442,0.001089176,0.0003638305,0.006859013,0.002229406,0.8824649,0.02810847,0.01699467,0.04560095],"study_design_scores_gemma":[0.02214483,0.003423315,0.01737552,0.002076434,0.002242198,0.001817902,0.0008824964,0.8197952,0.1199339,0.008280256,0.001522046,0.00050593],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9287491,0.002956852,0.0641841,0.001069644,0.0002635576,0.0006554225,0.00001611048,0.00003046903,0.002074761],"genre_scores_gemma":[0.9959215,0.00004332248,0.001788127,0.0004422491,0.0004210453,0.00003114193,0.0001142594,0.00001856797,0.001219802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8175658,"threshold_uncertainty_score":0.5586665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692651604237169,"score_gpt":0.2936596442615698,"score_spread":0.2467331282191981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}