{"id":"W4413108416","doi":"10.1016/j.jmb.2025.169381","title":"Recurrent Acrodysostosis-Related PKA RIα Mutant Reveals a Novel Mechanism of Aberrant PKA Deactivation","year":2025,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Protein kinase A; Mutant; Mutation; Protein subunit; Cell biology; Chemistry; Gene isoform; Ligand (biochemistry); Biophysics; Kinase; Biology; Biochemistry; Enzyme; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009069267,0.0003783936,0.0002839784,0.000134886,0.0001213075,0.0001721855,0.000303409,0.0003781713,0.0006439875],"category_scores_gemma":[0.0001165457,0.0001556401,0.0003625263,0.0001493153,0.0003340241,0.000173663,0.0002653441,0.0006779572,0.0003378575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252358,"about_ca_system_score_gemma":0.0001454422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008158055,"about_ca_topic_score_gemma":0.0005571606,"domain_scores_codex":[0.9999006,0.00001186288,0.00001663785,0.00002846785,0.00002780733,0.00001459954],"domain_scores_gemma":[0.9998862,0.00001430943,0.00005118825,0.0000113196,0.000007143896,0.00002995641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006601629,0.00001458545,0.0001989869,0.00001828539,0.000006043279,0.0003411969,0.00001421353,0.0001581697,0.9986739,0.00006367716,0.00002065277,0.0004242441],"study_design_scores_gemma":[0.00003668643,0.0003456662,0.009861319,0.00001001923,0.00002894708,0.003117057,0.00005422507,0.004593494,0.9801624,0.0001310177,0.001640699,0.00001840624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965695,0.0003407358,0.002369446,0.00007375067,0.00001832551,0.00001360716,0.000237871,0.00007088861,0.0003058994],"genre_scores_gemma":[0.9953335,0.0003233999,0.002931672,0.00004477552,0.000006423116,0.00001310481,0.0003460128,0.00002784963,0.0009732709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008158055,"threshold_uncertainty_score":0.00215441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101470802188647,"score_gpt":0.2765905266360268,"score_spread":0.2664434464171621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}