{"id":"W4413108439","doi":"10.1016/j.modpat.2025.100868","title":"Clinicopathologic and Genomic Characterization of SMARCA4-Deficient Carcinoma of the Gallbladder","year":2025,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Beijing Institute of Genomics, Chinese Academy of Sciences; Key Research and Development Projects of Shaanxi Province; Geneseeq Technology; National Natural Science Foundation of China; Xi'an Jiaotong University","keywords":"SMARCA4; Tissue microarray; Pathology; Biology; Immunohistochemistry; Gallbladder; Hematopathology; Carcinoma; Cancer research; Medicine; Chromatin remodeling; Internal medicine; Chromatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001568652,0.00007746428,0.0001476338,0.00002900062,0.00003346796,0.000002448855,0.0001261897,0.0001230545,0.000003696387],"category_scores_gemma":[0.00003616623,0.00005867181,0.00005878315,0.00004819376,0.0001545937,9.498251e-7,0.0001633504,0.00005184764,3.143975e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006166074,"about_ca_system_score_gemma":0.00006546784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005285607,"about_ca_topic_score_gemma":0.000005137289,"domain_scores_codex":[0.9993238,0.00008194105,0.0002336789,0.0002172377,0.0000431422,0.0001002274],"domain_scores_gemma":[0.9994795,0.000007525963,0.0001248253,0.0003174621,0.00005899793,0.00001167457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003010684,0.00003160104,0.03191582,0.00003540561,0.000006920304,6.544902e-7,0.00009550997,0.0001152851,0.9638813,0.00006896125,0.00001305139,0.003805437],"study_design_scores_gemma":[0.0005915487,0.000163115,0.6048869,0.00002663239,0.00004074707,0.00002935234,0.00003249662,0.004000382,0.3891514,0.0006934351,0.000280688,0.0001033543],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910095,0.0007445521,0.007493605,0.0001047572,0.0001558327,0.0001150041,0.00002532228,0.000003392247,0.0003480254],"genre_scores_gemma":[0.9991795,0.0001080738,0.0001437079,0.0002324882,0.00002002762,0.000008517041,0.00002163887,0.000006511113,0.0002794956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5747299,"threshold_uncertainty_score":0.2392567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007838858207914553,"score_gpt":0.2363423215010196,"score_spread":0.2285034632931051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}