{"id":"W4413108439","doi":"10.1016/j.modpat.2025.100868","title":"Clinicopathologic and Genomic Characterization of SMARCA4-Deficient Carcinoma of the Gallbladder","year":2025,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Beijing Institute of Genomics, Chinese Academy of Sciences; Key Research and Development Projects of Shaanxi Province; Geneseeq Technology; National Natural Science Foundation of China; Xi'an Jiaotong University","keywords":"SMARCA4; Tissue microarray; Pathology; Biology; Immunohistochemistry; Gallbladder; Hematopathology; Carcinoma; Cancer research; Medicine; Chromatin remodeling; Internal medicine; Chromatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039473,0.0004057871,0.0003113897,0.001765701,0.0004474611,0.0004823147,0.0003506996,0.0004699749,0.001439189],"category_scores_gemma":[0.0009823972,0.0003654358,0.0002593241,0.0009209627,0.0007458548,0.0003679126,0.0004098303,0.0002722971,0.0002839454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225998,"about_ca_system_score_gemma":0.0002270007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006943581,"about_ca_topic_score_gemma":0.0005547188,"domain_scores_codex":[0.9998131,0.0000316443,0.00002849744,0.00004248439,0.0000331613,0.0000511788],"domain_scores_gemma":[0.9994552,0.0001542988,0.0001138367,0.00008600948,0.00004361988,0.0001472065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001886336,0.00007767937,0.6812611,0.0001173764,0.00006597859,0.1711901,0.0005193631,0.0005489008,0.1370052,0.0008467974,0.0002934423,0.006187735],"study_design_scores_gemma":[0.00004952925,0.0003098975,0.5915119,0.00002117109,0.00018384,0.3781381,0.00112006,0.002342104,0.02334474,0.0007453008,0.002201138,0.0000322965],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979448,0.0003808008,0.0004032999,0.00003636228,0.000003776331,0.00001049998,0.00007320975,0.00001374946,0.001133583],"genre_scores_gemma":[0.9995695,0.00008989858,0.0001607278,0.000007677801,0.000005075583,0.000003187911,0.00005949549,0.000002446101,0.0001020044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765701,"threshold_uncertainty_score":0.004814565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007838858207914553,"score_gpt":0.2363423215010196,"score_spread":0.2285034632931051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}