{"id":"W4413110668","doi":"10.1513/annalsats.202501-028oc","title":"Multicenter Study of Hyperpolarized Xenon Magnetic Resonance Imaging in Children with Cystic Fibrosis Following Initiation of Cystic Fibrosis Transmembrane Regulator Modulator Therapy (HyPOINT)","year":2025,"lang":"en","type":"article","venue":"Annals of the American Thoracic Society","topic":"Atomic and Subatomic Physics Research","field":"Physics and Astronomy","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; Cystic Fibrosis Foundation","keywords":"Medicine; Ivacaftor; Spirometry; Cystic fibrosis; Magnetic resonance imaging; Ventilation (architecture); Lung function; Lung; Internal medicine; Lung disease; Nuclear medicine; Cardiology; Radiology; Cystic fibrosis transmembrane conductance regulator; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000409571,0.0002148458,0.000624379,0.00007410695,0.00009575969,0.00001650972,0.000416672,0.00002427061,0.000009777597],"category_scores_gemma":[0.00001618476,0.0001623641,0.0003910493,0.0009446422,0.0003133753,0.0001426271,0.00008871577,0.0002036908,4.305226e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003193073,"about_ca_system_score_gemma":0.0001776422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687481,"about_ca_topic_score_gemma":0.000004190662,"domain_scores_codex":[0.9981667,0.0003169647,0.000509144,0.0003178406,0.0003838362,0.0003054598],"domain_scores_gemma":[0.9986381,0.0002484714,0.0004064647,0.0005237019,0.0001425201,0.00004073688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006935636,0.0007487938,0.8667806,0.00004026915,0.0002892369,1.435057e-7,0.003326242,0.0002702629,0.04590484,0.00004960983,0.0000313198,0.08186512],"study_design_scores_gemma":[0.002473933,0.0002115057,0.9326574,0.0003453603,0.0001217987,1.819403e-7,0.00540042,0.01381507,0.04412891,0.0006219328,0.000008493791,0.0002150033],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966154,0.0006490681,0.001691953,0.0001263504,0.00002153006,0.0007725591,0.00006242847,0.00001046333,0.00005032115],"genre_scores_gemma":[0.9989289,0.00002685259,0.0008448934,0.00007403736,0.00001983282,0.00004227587,0.000008794364,0.00002640322,0.00002798329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08165012,"threshold_uncertainty_score":0.6621014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119819614254255,"score_gpt":0.3287112752326409,"score_spread":0.3075130790900983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}