{"id":"W4413110695","doi":"10.1021/acs.biomac.5c01319","title":"Investigation on Active and Rapid Hepatobiliary Excretion of Triantennary <i>N</i>-Acetyl Galactosamine Conjugated Polymeric Nanoparticles","year":2025,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of British Columbia; Canada Research Chairs; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Chemistry; Excretion; Conjugated system; In vivo; Asialoglycoprotein receptor; Nanoparticle; Biodistribution; Intracellular; Biophysics; Hepatocyte; Biochemistry; In vitro; Nanotechnology; Polymer; Organic chemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261414,0.0001958811,0.0001659492,0.00006680916,0.00007718348,0.000188538,0.0001095561,0.0001768114,0.0002688722],"category_scores_gemma":[0.0001773818,0.0000720816,0.0001464897,0.00006240601,0.0001584359,0.0001845805,0.00008057198,0.0001386175,0.0000907759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489423,"about_ca_system_score_gemma":0.0001226506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003473125,"about_ca_topic_score_gemma":0.0003215294,"domain_scores_codex":[0.9999094,0.00002351625,0.000006041558,0.00001567373,0.00002505561,0.00002029979],"domain_scores_gemma":[0.9999005,0.0000276656,0.00002928355,0.000008638305,0.00002172227,0.00001219449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000531255,0.000008971975,0.00007738949,0.00002529104,0.00000207057,0.00002311559,0.00001055636,0.00006059327,0.9990239,0.00005127523,0.000005828129,0.0006580224],"study_design_scores_gemma":[0.000002715951,0.0001678394,0.000534078,0.000001320431,0.000004418373,0.00004299653,0.000006487488,0.0004837013,0.9984713,0.000008981649,0.0002741807,0.000001909355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955364,0.0005674835,0.003009406,0.00002247183,0.000005551389,0.00001815574,0.00002957412,0.00001839212,0.0007925334],"genre_scores_gemma":[0.9963598,0.0004103844,0.002345664,0.00002709614,0.000003344599,0.00001420761,0.00005034735,0.00001169745,0.0007774563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003473125,"threshold_uncertainty_score":0.001195967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609817444834092,"score_gpt":0.2323543258158867,"score_spread":0.2162561513675458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}