{"id":"W4413110695","doi":"10.1021/acs.biomac.5c01319","title":"Investigation on Active and Rapid Hepatobiliary Excretion of Triantennary <i>N</i>-Acetyl Galactosamine Conjugated Polymeric Nanoparticles","year":2025,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of British Columbia; Canada Research Chairs; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Chemistry; Excretion; Conjugated system; In vivo; Asialoglycoprotein receptor; Nanoparticle; Biodistribution; Intracellular; Biophysics; Hepatocyte; Biochemistry; In vitro; Nanotechnology; Polymer; Organic chemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002785534,0.0002217966,0.0003144947,0.0002195413,0.0001176532,0.00004734093,0.0001615571,0.00009680733,0.00006933487],"category_scores_gemma":[0.0001847533,0.0002045153,0.00006146497,0.0005761885,0.0005244622,0.0002143815,0.00009483265,0.00006533232,0.00003121427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005094698,"about_ca_system_score_gemma":0.0001191506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001468188,"about_ca_topic_score_gemma":0.000009705027,"domain_scores_codex":[0.9982648,0.0002970195,0.0004524989,0.0004470182,0.0002432681,0.000295392],"domain_scores_gemma":[0.9990111,0.0002302202,0.0002106501,0.0003311656,0.0001071374,0.0001097301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007220163,0.000114748,0.0006913227,0.00006358625,0.00002310672,0.00001579024,0.0001561351,0.000002659318,0.9937794,0.000601568,0.0001745237,0.003655101],"study_design_scores_gemma":[0.001255192,0.0004492039,0.004719448,0.0001652899,0.00004967507,0.000008062511,0.0001716145,0.0004519608,0.9921566,0.0003349907,0.00005214128,0.0001858414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973209,0.0008639171,0.0001009129,0.0006973943,0.0002293363,0.0003748435,0.00008381795,0.0001264088,0.0002024845],"genre_scores_gemma":[0.9990241,0.00006991098,0.0003650552,0.0003975488,0.00001979323,0.00003628783,0.00003041639,0.00001797967,0.00003892401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004028126,"threshold_uncertainty_score":0.833989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609817444834092,"score_gpt":0.2323543258158867,"score_spread":0.2162561513675458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}