{"id":"W4413110887","doi":"10.1038/s42255-025-01339-1","title":"d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Oncosuisse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondation Ernst et Lucie Schmidheiny; Deutsche Forschungsgemeinschaft","keywords":"Cancer cell; Cell biology; Cystine; Intracellular; Mitochondrion; Cysteine; Chemistry; Biochemistry; Biology; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113009,0.0002822256,0.000238567,0.0001946117,0.0001105742,0.0001541276,0.0002118953,0.0002292381,0.0009889515],"category_scores_gemma":[0.0001053497,0.00008052758,0.0001627079,0.0001196679,0.0001796873,0.0001193537,0.0001292772,0.0003354969,0.0001688383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549328,"about_ca_system_score_gemma":0.000269942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001169418,"about_ca_topic_score_gemma":0.001457684,"domain_scores_codex":[0.9999074,0.00002119061,0.00001197063,0.0000159101,0.00002010308,0.00002344515],"domain_scores_gemma":[0.999921,0.00001575594,0.00002146675,0.00001070236,0.000009235077,0.00002196769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005053983,0.00008203903,0.0001634832,0.00003747227,0.000007911381,0.00002964789,0.00001173502,0.00007141766,0.9966729,0.00007190021,0.00007724699,0.002268776],"study_design_scores_gemma":[0.00003420991,0.001010118,0.001193001,0.000003919484,0.00001186001,0.0001112828,0.00001639482,0.0004776378,0.9947554,0.00002725928,0.002356775,0.000002259161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956048,0.001871635,0.0009072443,0.0001220479,0.00003038038,0.0000199462,0.0002210327,0.0001046196,0.001118367],"genre_scores_gemma":[0.9966477,0.0008890408,0.0006435321,0.00003113597,0.000006070828,0.00002016807,0.0002588529,0.0000126629,0.001490894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169418,"threshold_uncertainty_score":0.003308415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004969662631261753,"score_gpt":0.2877640874048724,"score_spread":0.2827944247736106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}