{"id":"W4413111259","doi":"10.1093/bjd/ljaf293","title":"Tyrosine kinase 2 inhibition improves clinical and molecular hallmarks in subtypes of cutaneous lupus","year":2025,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; Deutsche Forschungsgemeinschaft","keywords":"Cutaneous Lupus Erythematosus; Systemic lupus erythematosus; Medicine; Lupus erythematosus; Computational biology; Biology; Dermatology; Immunology; Disease; Pathology; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472776,0.0003866273,0.000515951,0.0001733173,0.0001135078,0.0002855051,0.0002058745,0.0002320308,0.002110429],"category_scores_gemma":[0.0001556819,0.00006636758,0.0002348472,0.00008367003,0.000120431,0.0001527749,0.00009448756,0.0006475103,0.0003866836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513147,"about_ca_system_score_gemma":0.0001379574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001711577,"about_ca_topic_score_gemma":0.0003468184,"domain_scores_codex":[0.9999045,0.00001681154,0.000009682586,0.00002146378,0.00001938146,0.00002809241],"domain_scores_gemma":[0.9998931,0.00001532777,0.00002952987,0.00001312855,0.00001172534,0.00003716982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00630705,0.001186424,0.001576914,0.0002962826,0.00007970728,0.0001395224,0.00002736081,0.0004333639,0.9494388,0.00008682288,0.0006068661,0.0398209],"study_design_scores_gemma":[0.002039264,0.02651466,0.04580733,0.00007237159,0.0003424537,0.003401595,0.0001045143,0.003384377,0.9029738,0.0002460731,0.01508511,0.00002861908],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929956,0.003739255,0.0009034839,0.00008396092,0.00006114598,0.00004481675,0.0002197261,0.0002028357,0.001749071],"genre_scores_gemma":[0.9970305,0.0006815116,0.0004623664,0.00005416124,0.00001960971,0.00002325191,0.0003348698,0.00002063366,0.001372977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002110429,"threshold_uncertainty_score":0.007060051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080450474758273,"score_gpt":0.309357202867814,"score_spread":0.2985526981202313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}