{"id":"W4413111594","doi":"10.1038/s42004-025-01627-7","title":"Investigation of a squaramide motif as a bioisostere of the amino-acid group of S-adenosyl-L-methionine and its functional impact on RNA methylation","year":2025,"lang":"en","type":"article","venue":"Communications Chemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chinese Government Scholarship; Institut Universitaire de France; China Scholarship Council; Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; Sidaction","keywords":"Methyltransferase; Squaramide; RNA; Methionine; Biochemistry; Methylation; Chemistry; Moiety; Stereochemistry; Amino acid; Biology; DNA; Catalysis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442801,0.0003433563,0.0001920579,0.0001195705,0.0001130996,0.0001211785,0.0002925603,0.000322435,0.001315004],"category_scores_gemma":[0.0001435562,0.0001014479,0.0002793872,0.0001124059,0.000160139,0.000301432,0.0002337767,0.0004349426,0.0003404558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001424484,"about_ca_system_score_gemma":0.0001799578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003526604,"about_ca_topic_score_gemma":0.0006297937,"domain_scores_codex":[0.9999459,0.00001222798,0.000004388974,0.00001256681,0.000009975221,0.00001493866],"domain_scores_gemma":[0.9999492,0.000008866135,0.00001451671,0.000005100374,0.000008138095,0.00001422183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002479494,0.00008936843,0.0001827726,0.0003427757,0.00002245828,0.0003389101,0.00004037127,0.0005511951,0.9888187,0.0010099,0.0001524421,0.008203111],"study_design_scores_gemma":[0.00007904523,0.003275059,0.0006436384,0.00002337638,0.00003624204,0.0003935115,0.00003168928,0.001235691,0.9841844,0.000195863,0.009881658,0.00001974701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757761,0.008152956,0.006512119,0.0003691003,0.0001103291,0.0001238619,0.0003084434,0.00008028612,0.008566875],"genre_scores_gemma":[0.9892445,0.003574049,0.00470443,0.0001076328,0.00002388742,0.00004130018,0.0002327023,0.00001256065,0.002058856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315004,"threshold_uncertainty_score":0.004399121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0258566847007338,"score_gpt":0.2902668486628043,"score_spread":0.2644101639620705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}