{"id":"W4413112080","doi":"10.1093/jncics/pkaf079","title":"MammaPrint predicts chemotherapy benefit in HR+HER2- early breast cancer: FLEX Registry real-world data","year":2025,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Medicine; Internal medicine; Oncology; Chemotherapy; Breast cancer; Proportional hazards model; Cancer; Stage (stratigraphy); Clinical endpoint; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00415731,0.0002845491,0.0004543189,0.0005512922,0.0001313189,0.0006381189,0.0004347836,0.0002678784,0.001506354],"category_scores_gemma":[0.007763724,0.000135654,0.0005759625,0.001140601,0.0002031922,0.0004675983,0.0005699899,0.0003949883,0.0003969903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003146179,"about_ca_system_score_gemma":0.0002806457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179149,"about_ca_topic_score_gemma":0.001805003,"domain_scores_codex":[0.9981813,0.001004753,0.0001826312,0.0003137056,0.0002352995,0.00008227306],"domain_scores_gemma":[0.9929484,0.002263669,0.003123924,0.001152392,0.000299105,0.0002124794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002132989,0.00008389754,0.9902447,0.00003676537,0.0002901135,0.00003202729,0.00002064519,0.001350585,0.0002632209,0.00006442636,0.0006888619,0.00479157],"study_design_scores_gemma":[0.0002781138,0.0006274915,0.9889293,0.00002340126,0.0003989617,0.0003619309,0.00006623773,0.006233596,0.0007692458,0.0001938528,0.002099748,0.00001817834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907094,0.0003322477,0.0006178838,0.0001038589,0.00000701371,0.00003339834,0.007496832,0.00001854888,0.0006808477],"genre_scores_gemma":[0.9919811,0.00006692616,0.0004708562,0.00004232637,0.00001357947,0.0000346631,0.007283934,0.000005609775,0.0001010411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00415731,"threshold_uncertainty_score":0.02198619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484008844366644,"score_gpt":0.306056503390972,"score_spread":0.2912164149473055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}