{"id":"W4413112080","doi":"10.1093/jncics/pkaf079","title":"MammaPrint predicts chemotherapy benefit in HR+HER2- early breast cancer: FLEX Registry real-world data","year":2025,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Medicine; Internal medicine; Oncology; Chemotherapy; Breast cancer; Proportional hazards model; Cancer; Stage (stratigraphy); Clinical endpoint; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001346116,0.0003990569,0.0004354803,0.000142403,0.0001161804,0.00005537554,0.0008618967,0.0001404385,0.0001377671],"category_scores_gemma":[0.000009475641,0.0003930883,0.00009375446,0.0005412429,0.0001944544,0.00001668588,0.0005700082,0.0002269875,0.000007851349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005165439,"about_ca_system_score_gemma":0.0004800821,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.05977558,"about_ca_topic_score_gemma":0.1568182,"domain_scores_codex":[0.9976119,0.0000339171,0.000378107,0.001107156,0.0002383746,0.0006304975],"domain_scores_gemma":[0.998017,0.00001526163,0.0001836093,0.001616575,0.00006290621,0.0001046098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001212129,0.0002314484,0.9379973,0.00009253559,0.0006633836,0.00002399928,0.0001186383,0.0001087918,0.003308971,0.0006788392,0.02007873,0.03548525],"study_design_scores_gemma":[0.001919539,0.00005601532,0.9476361,0.0002222793,0.00007156171,0.000007112576,0.00004513876,0.00004349141,0.01745555,0.000324928,0.03184959,0.0003687402],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598165,0.004727826,0.00006505795,0.02371038,0.0009834862,0.0005516899,0.001826095,0.00008896607,0.008230026],"genre_scores_gemma":[0.9777619,0.01353619,0.0001488215,0.001107121,0.001020302,0.0003131939,0.0002168608,0.00005843089,0.005837189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09704259,"threshold_uncertainty_score":0.9998521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484008844366644,"score_gpt":0.306056503390972,"score_spread":0.2912164149473055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}