{"id":"W4413112197","doi":"10.1093/eurheartj/ehaf380","title":"Titin-related familial dilated cardiomyopathy: factors associated with disease onset","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Data Research UK; Medical Research Future Fund; CHIST-ERA; HORIZON EUROPE European Innovation Council; National Human Genome Research Institute; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; National Heart, Lung, and Blood Institute; European Regional Development Fund; Centro Nacional de Investigaciones Cardiovasculares; Medical Research Council; Medical Research Council Canada; Bundesministerium für Bildung und Frauen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Hartstichting; ZonMw; Cardiac Society of Australia and New Zealand; National Heart Foundation of Australia; Instituto de Salud Carlos III; Amgen; National Health and Medical Research Council; European Society of Cardiology; Ministerio de Economía y Competitividad; Sarnoff Cardiovascular Research Foundation; British Heart Foundation; National Society of Genetic Counselors; Sir Jules Thorn Charitable Trust; National Institute on Aging; Abbott Laboratories; National Institute for Health and Care Research; NSW Ministry of Health; Howard Hughes Medical Institute; Cytokinetics; Sanofi; Hjerteforeningen; Alan Turing Institute; Wellcome Trust; National Institutes of Health; European Research Area Network on Cardiovascular Diseases; BioMarin Pharmaceutical; NIHR Imperial Biomedical Research Centre; Bristol-Myers Squibb Canada; European Commission; AstraZeneca; Alnylam Pharmaceuticals; Agence Nationale de la Recherche; Australian Government; Pfizer; Bristol-Myers Squibb; Ministerio de Ciencia e Innovación; Novo Nordisk; St. Vincent's Clinic Foundation; American Heart Association","keywords":"Medicine; Internal medicine; Odds ratio; Cardiology; Cardiomyopathy; Dilated cardiomyopathy; Confidence interval; Atrial fibrillation; Population; Risk factor; Heart failure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007401843,0.0004112753,0.0003755431,0.0006280551,0.0005376227,0.000537209,0.0003624308,0.000607827,0.0017994],"category_scores_gemma":[0.002500438,0.0001970288,0.0005404557,0.0009971823,0.0003559907,0.0003426693,0.0004215293,0.0006838757,0.0001847971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002887539,"about_ca_system_score_gemma":0.0003347078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002844027,"about_ca_topic_score_gemma":0.003192052,"domain_scores_codex":[0.9995089,0.0001353634,0.00005659139,0.0001481927,0.0000699197,0.00008105623],"domain_scores_gemma":[0.9969538,0.0005326587,0.001692829,0.000117553,0.0001529325,0.0005501801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000475528,0.00001007964,0.999299,0.000003643572,0.00001654344,0.0001269291,0.00001705105,0.00001507282,0.0001289707,0.000005946206,0.00002145737,0.0003076642],"study_design_scores_gemma":[0.000002205964,0.00003539178,0.9990976,0.000004547449,0.00001678241,0.0006597918,0.00003100149,0.00006941479,0.00002045801,0.00001727589,0.00004356703,0.000002083142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986843,0.0007225284,0.00009054649,0.00005137497,0.000007929208,0.000003984745,0.0001315488,0.000003633203,0.0003039493],"genre_scores_gemma":[0.9995707,0.0001250368,0.00007411704,0.00001368459,0.00001752922,0.000002414387,0.0001167144,0.000001596257,0.0000783259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002844027,"threshold_uncertainty_score":0.006019592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03072367322346554,"score_gpt":0.2788741527940459,"score_spread":0.2481504795705804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}