{"id":"W4413112615","doi":"10.1371/journal.ppat.1013063","title":"Structural determinants of rotavirus proteolytic activation","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación","keywords":"Proteolysis; Spike (software development); Biophysics; Infectivity; Proteases; Trypsin; Cell biology; Rotavirus; Chemistry; Conformational change; Biology; Biochemistry; Virus; Virology; Enzyme; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076563,0.0001797452,0.0001467752,0.0001684409,0.0001347539,0.0004393359,0.0001716291,0.0002809024,0.001245261],"category_scores_gemma":[0.0005551436,0.0001575603,0.0002478976,0.0001234059,0.0003059262,0.0002279987,0.0002696912,0.0004493559,0.0003715314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798298,"about_ca_system_score_gemma":0.0001764979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005165605,"about_ca_topic_score_gemma":0.0005323495,"domain_scores_codex":[0.9998028,0.0000475613,0.00001547468,0.00002750097,0.00004772004,0.0000589811],"domain_scores_gemma":[0.9995944,0.0001167001,0.0001093085,0.00004039172,0.00005236298,0.00008689886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001623767,0.00002210638,0.002662008,0.00002147757,0.000004933964,0.0002373421,0.00003687984,0.0002148401,0.9955148,0.0002825545,0.00003720988,0.0008035269],"study_design_scores_gemma":[0.00003035778,0.0005957246,0.1862497,0.00001946362,0.00002352373,0.002925318,0.0002932153,0.003561165,0.8035783,0.0003601291,0.002341629,0.00002155319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979526,0.0002733413,0.0007721557,0.00003127196,0.000004065389,0.000006716565,0.00005880282,0.000009723627,0.0008912875],"genre_scores_gemma":[0.9990814,0.00009524076,0.0004593004,0.00001968282,0.000003299328,0.000003768832,0.0001497886,0.000006040874,0.0001815047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245261,"threshold_uncertainty_score":0.004165828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176235371352315,"score_gpt":0.3413592785537121,"score_spread":0.2995969248401889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}