{"id":"W4413112615","doi":"10.1371/journal.ppat.1013063","title":"Structural determinants of rotavirus proteolytic activation","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación","keywords":"Proteolysis; Spike (software development); Biophysics; Infectivity; Proteases; Trypsin; Cell biology; Rotavirus; Chemistry; Conformational change; Biology; Biochemistry; Virus; Virology; Enzyme; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009966853,0.00007913134,0.0002861624,0.0001106345,0.00003409366,0.000003227218,0.00006345526,0.00005808466,0.00007007999],"category_scores_gemma":[0.0007154183,0.00006393754,0.00006782894,0.0001284893,0.00007086574,0.00004121755,0.00004540958,0.0001218264,0.0000103387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004134501,"about_ca_system_score_gemma":0.00006977545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002631632,"about_ca_topic_score_gemma":0.000008205495,"domain_scores_codex":[0.9991633,0.00006817628,0.0002463972,0.0001551115,0.0001264862,0.000240483],"domain_scores_gemma":[0.9995704,0.00001976366,0.00005918846,0.0001900591,0.00009113813,0.00006940992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003088989,0.00005095808,0.4528014,0.0002242537,0.00003760165,0.0000246288,0.00002671185,0.000001784938,0.5331354,0.00003470631,0.0001271561,0.01322645],"study_design_scores_gemma":[0.001096386,0.0006195512,0.820106,0.0004497858,0.0000488582,0.00002441529,0.00003968908,0.003322652,0.1737667,0.0003664082,0.0000968567,0.00006275414],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983707,0.0000320937,0.0001037059,0.0003289704,0.00003766879,0.0004741953,0.00001872001,0.00002116489,0.0006127706],"genre_scores_gemma":[0.9982177,0.00001539926,0.001034159,0.0002138416,0.00003791013,0.00004040865,0.00001216424,0.00000674257,0.0004216659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3673046,"threshold_uncertainty_score":0.2607297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176235371352315,"score_gpt":0.3413592785537121,"score_spread":0.2995969248401889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}