{"id":"W4413112632","doi":"10.1093/genetics/iyaf154","title":"Targeted loss of heterozygosity in <i>Candida albicans</i> using CRISPR-Cas9 reveals the functional impact of allelic variation","year":2025,"lang":"en","type":"article","venue":"Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Cambridge Arts Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Lauku atbalsta dienests; Canada Research Chairs; Methuselah Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"Biology; Loss of heterozygosity; CRISPR; Genetics; Allele; Candida albicans; Genetic variation; Variation (astronomy); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076135,0.0002613054,0.0002001436,0.0002309304,0.0001946536,0.0004547446,0.0003505021,0.0003195592,0.00129144],"category_scores_gemma":[0.0002835269,0.0001387352,0.0002520608,0.0001618681,0.0002872586,0.0001337472,0.0003049265,0.0007766955,0.0004049973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003227336,"about_ca_system_score_gemma":0.0002891934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018744,"about_ca_topic_score_gemma":0.00215829,"domain_scores_codex":[0.9997575,0.0000320404,0.00003271437,0.00006548882,0.00008076731,0.0000315971],"domain_scores_gemma":[0.9997949,0.00004946729,0.00007808926,0.00003073761,0.00001585667,0.00003098614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003894202,0.00001851572,0.0003062633,0.00002236271,0.000004965126,0.00007586506,0.00001208261,0.000200121,0.9960415,0.0002323072,0.0000954952,0.002951508],"study_design_scores_gemma":[0.000009561455,0.0001293046,0.004685963,0.00001037565,0.00001245834,0.0005523599,0.00002515924,0.002679051,0.9882244,0.0001265323,0.00352909,0.00001572864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553376,0.0006310389,0.03686909,0.0002277154,0.00007572491,0.0001028764,0.001560909,0.001079564,0.004115471],"genre_scores_gemma":[0.9757687,0.0004208316,0.01979723,0.000170621,0.00001061037,0.00005414607,0.001073073,0.0002548154,0.002450115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129144,"threshold_uncertainty_score":0.004320323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415054374255724,"score_gpt":0.3244832968208693,"score_spread":0.3003327530783121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}