{"id":"W4413113762","doi":"10.1186/s40478-025-02079-9","title":"Variably protease-sensitive prionopathy: mass spectrometry analysis of the pathogenic prion protein provides a new perspective","year":2025,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Creutzfeldt-Jakob Disease Foundation; National Institute of Neurological Disorders and Stroke; Centers for Disease Control and Prevention; National Institute on Aging; National Institutes of Health; Jewish Community Foundation","keywords":"Epitope; Protease; Molecular mass; Molecular biology; Epitope mapping; Peptide sequence; N-terminus; Proteinase K; C-terminus; Biology; Prion protein; Chemistry; Biochemistry; Amino acid; Antibody; Enzyme; Genetics; Gene; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001294095,0.001213532,0.000787738,0.001480283,0.0003733446,0.001504697,0.0009250402,0.001922451,0.0007851222],"category_scores_gemma":[0.0006164111,0.0003412701,0.0006123748,0.0007480169,0.0007867564,0.002135532,0.0005950448,0.001536347,0.0008372068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003001553,"about_ca_system_score_gemma":0.0002981548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003114372,"about_ca_topic_score_gemma":0.0005774958,"domain_scores_codex":[0.9995657,0.00007730498,0.00002867071,0.0001034002,0.0001834499,0.000041426],"domain_scores_gemma":[0.9994641,0.0001242215,0.0001308686,0.00006034668,0.0001239694,0.00009665828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432095,0.00009373503,0.002842938,0.0003135597,0.0001057081,0.0006193966,0.00009321914,0.00016829,0.9784585,0.001056581,0.0006909008,0.015414],"study_design_scores_gemma":[0.00004591387,0.001118356,0.05167497,0.000228678,0.0003288034,0.01565153,0.0006183753,0.01513739,0.8621102,0.008559372,0.04431087,0.0002155311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7309341,0.1101236,0.1414641,0.005681152,0.001063106,0.0001102557,0.001500213,0.001378143,0.007745342],"genre_scores_gemma":[0.7775421,0.04774795,0.163799,0.002574603,0.00136603,0.00007802294,0.001593247,0.0002654374,0.005033588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922451,"threshold_uncertainty_score":0.006843865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459060833927089,"score_gpt":0.2716548693707454,"score_spread":0.2570642610314745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}