{"id":"W4413115468","doi":"10.1111/bdi.70048","title":"Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <scp>ISBD</scp> Task Force","year":2025,"lang":"en","type":"article","venue":"Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; Idorsia Pharmaceuticals; H. Lundbeck A/S; National Natural Science Foundation of China; Canadian Institutes of Health Research; Sunovion; Novo Nordisk; Purdue University; Eisai; Sanofi; Pfizer; Bausch Health; Georgia Clinical and Translational Science Alliance; AstraZeneca; Eli Lilly and Company","keywords":"Task force; Depression (economics); Bipolar disorder; Task (project management); Psychology; Medicine; Psychiatry; Political science; Cognition; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06720825,0.002891288,0.005527191,0.006460309,0.00230704,0.00425242,0.01100467,0.00992475,0.004616956],"category_scores_gemma":[0.08407567,0.00149725,0.008831809,0.006389601,0.00242098,0.00424172,0.004607706,0.0136108,0.005145798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00780897,"about_ca_system_score_gemma":0.03906392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04460714,"about_ca_topic_score_gemma":0.04607101,"domain_scores_codex":[0.9654689,0.01248142,0.01231077,0.001263048,0.007021627,0.001454226],"domain_scores_gemma":[0.8605976,0.04288263,0.01456752,0.003552793,0.07139641,0.007003042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000261792,0.0002963982,0.002590679,0.01329045,0.0003384627,0.0002348768,0.0005170545,0.0009290096,0.0005147477,0.005528093,0.6179428,0.3575557],"study_design_scores_gemma":[0.001132061,0.0003365142,0.01396665,0.1340062,0.00175807,0.0007329581,0.0008951477,0.002022325,0.0007587863,0.01148078,0.8327013,0.0002091351],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.003232677,0.3564771,0.03583157,0.513947,0.02492032,0.01295628,0.01147807,0.001486633,0.03967043],"genre_scores_gemma":[0.02454141,0.4308678,0.2591973,0.1782694,0.01662108,0.03043108,0.04272927,0.001200331,0.01614235],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.06720825,"threshold_uncertainty_score":0.3554355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049967387637968,"score_gpt":0.2650995378813905,"score_spread":0.2545998640050108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}