{"id":"W4413116457","doi":"10.1016/j.annonc.2025.07.012","title":"Imatinib’s last lessons? A roadmap to cure","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"GlaxoSmithKline; MSD","keywords":"Medicine; Imatinib; Imatinib mesylate; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008561702,0.001356636,0.002442193,0.001923479,0.001846122,0.006621766,0.002019319,0.01175538,0.03519858],"category_scores_gemma":[0.0127531,0.0005963524,0.001929841,0.0009456195,0.005202873,0.01473967,0.003996438,0.01894324,0.008727342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00363576,"about_ca_system_score_gemma":0.009674743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001597558,"about_ca_topic_score_gemma":0.006112132,"domain_scores_codex":[0.9966696,0.001122234,0.0002977694,0.0003505238,0.0007267969,0.0008331595],"domain_scores_gemma":[0.986289,0.00652033,0.0007285902,0.0003302131,0.001934838,0.004197067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007208853,0.0004003122,0.000683939,0.001931469,0.0001341993,0.001140218,0.0002558449,0.001035834,0.0008224839,0.05558943,0.633779,0.3035063],"study_design_scores_gemma":[0.0005436481,0.00066069,0.0008033793,0.002974003,0.0001546886,0.001248306,0.0007912145,0.001009922,0.0003143745,0.1004031,0.8909931,0.0001035185],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001249611,0.3464695,0.001969352,0.6112128,0.02591064,0.00003611204,0.0003153995,0.0003072351,0.01252932],"genre_scores_gemma":[0.04846158,0.4880293,0.006596857,0.3405795,0.09766646,0.0002202954,0.0008919489,0.0002307215,0.01732318],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03519858,"threshold_uncertainty_score":0.1177509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1431864757456521,"score_gpt":0.5069355149283589,"score_spread":0.3637490391827067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}