{"id":"W4413116808","doi":"10.1007/s00425-025-04792-0","title":"Discovery of corynanthe synthases in Camptotheca acuminata: medium-chain dehydrogenase/reductase-based gateway to corynanthe-type compound diversification","year":2025,"lang":"en","type":"article","venue":"Planta","topic":"Plant Diversity and Evolution","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia, Okanagan Campus","funders":"Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Michael Smith Health Research BC","keywords":"Biochemistry; Enzyme; Biology; Reductase; Biosynthesis; Dehydrogenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285148,0.0001312556,0.0002212437,0.0000721652,0.0001577738,0.00003031456,0.0003240294,0.00008768233,0.00006579475],"category_scores_gemma":[0.0001044195,0.00006376817,0.00005382088,0.0005079055,0.00009431673,0.0001626441,0.00008030143,0.00008231402,0.00003383122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006799657,"about_ca_system_score_gemma":0.00003588408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001643115,"about_ca_topic_score_gemma":0.001846876,"domain_scores_codex":[0.9990131,0.00008755778,0.000206679,0.0002747725,0.0001837367,0.0002341686],"domain_scores_gemma":[0.999283,0.0004512594,0.00008939714,0.00008027543,0.0000424266,0.00005360004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008203754,0.0003290467,0.04187145,0.00004934952,0.00002824541,0.00003274801,0.0001570886,0.0001416178,0.9490544,0.0005440562,0.006048355,0.0009232305],"study_design_scores_gemma":[0.0007806223,0.0003899096,0.3779923,0.0006710312,0.00009787811,0.00001525416,0.002327846,0.001153637,0.6075159,0.0002961425,0.008225352,0.0005341657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996465,0.0001045786,0.00002371588,0.001064449,0.0002537005,0.0002342916,0.001489394,0.00002994381,0.0003349587],"genre_scores_gemma":[0.9987761,0.00006601338,0.00002320603,0.000166079,0.00002797508,0.000004196785,0.0007426045,6.360209e-7,0.0001932224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3415386,"threshold_uncertainty_score":0.2600391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089353632102135,"score_gpt":0.2201718425172434,"score_spread":0.199278306196222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}