{"id":"W4413117173","doi":"10.3390/ani15152199","title":"Natural Product-Induced Modulation of Androstenone Metabolism in Porcine Hepatocytes","year":2025,"lang":"en","type":"article","venue":"Animals","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Swine Innovation Porc","keywords":"Androstenone; Pregnane X receptor; Constitutive androstane receptor; Farnesoid X receptor; Internal medicine; Endocrinology; Nuclear receptor; Boar taint; Downregulation and upregulation; Metabolism; Lipid metabolism; Biology; Chemistry; Pharmacology; Biochemistry; Medicine; Immunology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827895,0.0001046524,0.0003749045,0.0001889689,0.00002013252,0.000003861722,0.00005108351,0.00005079758,0.00003177056],"category_scores_gemma":[0.00003813486,0.00008251731,0.00006319885,0.0003788205,0.00002137046,0.00005586821,0.00001066309,0.0001109273,0.000003327553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001970835,"about_ca_system_score_gemma":0.00007019529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007382974,"about_ca_topic_score_gemma":0.00005820768,"domain_scores_codex":[0.9991624,0.00001561253,0.0003081352,0.0002053755,0.0001536956,0.0001548006],"domain_scores_gemma":[0.9996039,0.00001404058,0.00006236196,0.000189282,0.0001020063,0.00002835783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003712715,0.00009746448,0.02994072,0.0001618473,0.00003650835,0.00002226772,0.0001352358,0.000002483059,0.9631624,0.003712054,0.00004165625,0.002316075],"study_design_scores_gemma":[0.001143961,0.00004660952,0.6129686,0.0001682486,0.00005689303,0.000003047493,0.00005703828,0.000163174,0.3845069,0.000506628,0.0003179638,0.00006098181],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939577,0.002889412,0.00003200841,0.0008625677,0.0002014226,0.0004282049,0.000003364528,0.00002888338,0.001596436],"genre_scores_gemma":[0.9977374,0.00006173613,0.0006790165,0.0001027758,0.00005356797,0.0000122393,0.00001964071,0.000009337899,0.001324285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5830279,"threshold_uncertainty_score":0.3364958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161776177561573,"score_gpt":0.2711013924876729,"score_spread":0.2594836307120572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}