{"id":"W4413117173","doi":"10.3390/ani15152199","title":"Natural Product-Induced Modulation of Androstenone Metabolism in Porcine Hepatocytes","year":2025,"lang":"en","type":"article","venue":"Animals","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Swine Innovation Porc","keywords":"Androstenone; Pregnane X receptor; Constitutive androstane receptor; Farnesoid X receptor; Internal medicine; Endocrinology; Nuclear receptor; Boar taint; Downregulation and upregulation; Metabolism; Lipid metabolism; Biology; Chemistry; Pharmacology; Biochemistry; Medicine; Immunology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260891,0.0001925357,0.0002207162,0.0001839117,0.00009482696,0.000247322,0.00006320135,0.000152978,0.001150414],"category_scores_gemma":[0.00009726897,0.000120142,0.0003869328,0.0001480028,0.0001786029,0.0001146308,0.0001373651,0.0002660846,0.0003378745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706897,"about_ca_system_score_gemma":0.0001839672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006699622,"about_ca_topic_score_gemma":0.001069247,"domain_scores_codex":[0.9998856,0.00002681619,0.00001097824,0.00002708932,0.00002379892,0.00002566508],"domain_scores_gemma":[0.9999303,0.00001716794,0.00001359704,0.00001040869,0.00001330729,0.00001525272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003986185,0.00002952986,0.0005384412,0.00004908249,0.000006616223,0.00009402495,0.00002470041,0.00003257625,0.9977599,0.00001668633,0.0000240339,0.001025719],"study_design_scores_gemma":[0.00005040371,0.00226093,0.04212445,0.00001002428,0.00003792633,0.0003620266,0.0002173854,0.0004511186,0.9519472,0.00003753362,0.002488111,0.00001298908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996007,0.001504954,0.0006562383,0.0000519325,0.0000451336,0.00002162785,0.0003327735,0.00001742882,0.001362914],"genre_scores_gemma":[0.9940292,0.001177735,0.0008467706,0.00009181945,0.00001949695,0.00004205035,0.000772755,0.00001015832,0.003010031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001150414,"threshold_uncertainty_score":0.003848553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161776177561573,"score_gpt":0.2711013924876729,"score_spread":0.2594836307120572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}