{"id":"W4413120292","doi":"10.1101/2025.08.06.668884","title":"A blastocyst-derived <i>in vitro</i> model of the <i>human</i> chorion","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Gates Cambridge Trust; UK Research and Innovation; HORIZON EUROPE Framework Programme; Government of the United Kingdom; Medical Research Council; Cambridge Trust; Wellcome Trust","keywords":"Trophoblast; Blastocyst; Biology; Cell biology; Placenta; Mesoderm; Organoid; Inner cell mass; Andrology; Embryo; Immunology; Embryonic stem cell; Fetus; Embryogenesis; Genetics; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005116694,0.0006322752,0.000344309,0.0004326676,0.0005795849,0.0007706114,0.0006393983,0.000791945,0.003832471],"category_scores_gemma":[0.0002632767,0.0004089041,0.0004151329,0.0002525956,0.0006013224,0.0003813014,0.0005301815,0.001390492,0.001819782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005763136,"about_ca_system_score_gemma":0.0007048683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00625374,"about_ca_topic_score_gemma":0.005608507,"domain_scores_codex":[0.9996421,0.00008273203,0.00004358025,0.00008699048,0.0001097084,0.00003474276],"domain_scores_gemma":[0.999783,0.00005402556,0.00003595969,0.00005745892,0.00002006928,0.0000494749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001700923,0.00004845025,0.0005708401,0.0001863545,0.00002314733,0.0009261649,0.0001494104,0.0008968217,0.988257,0.004759071,0.001308262,0.002704368],"study_design_scores_gemma":[0.00004766878,0.0002804058,0.002952357,0.0001006257,0.00007543941,0.001607178,0.0001285407,0.005225735,0.9219824,0.0007519968,0.06682245,0.0000252534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7137306,0.01118807,0.1465926,0.002410157,0.001228552,0.0012919,0.01660276,0.002386317,0.1045691],"genre_scores_gemma":[0.8856346,0.004686742,0.05902065,0.0004790759,0.00007716785,0.0005060016,0.009067914,0.0003758865,0.04015201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00625374,"threshold_uncertainty_score":0.01282084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637824892759167,"score_gpt":0.2338695125055379,"score_spread":0.2174912635779462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}