{"id":"W4413127918","doi":"10.3390/vaccines13080853","title":"Freeze-Drying of mRNA-LNPs Vaccines: A Review","year":2025,"lang":"en","type":"review","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Bee Research Fund","keywords":"Messenger RNA; Scalability; Biochemical engineering; Protein stability; Freeze-drying; Nanotechnology; Process (computing); Computer science; Chemistry; Materials science; Engineering; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005118189,0.000952759,0.001146156,0.002159874,0.0002891857,0.0008154833,0.0006361888,0.0008730706,0.003243835],"category_scores_gemma":[0.0005788077,0.000406465,0.0006277086,0.001717081,0.0002947272,0.001151738,0.0004745127,0.001060234,0.001779777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000386786,"about_ca_system_score_gemma":0.0008661935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009017079,"about_ca_topic_score_gemma":0.001179195,"domain_scores_codex":[0.9997941,0.00002776152,0.00003110425,0.00003932972,0.00008927649,0.00001845924],"domain_scores_gemma":[0.9997222,0.00015362,0.00004814069,0.000007846238,0.00005502791,0.00001318467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006552734,0.0001276061,0.0001811367,0.04440508,0.0001223694,0.0002395739,0.00009750146,0.0007520238,0.01177933,0.003541118,0.01576401,0.9229248],"study_design_scores_gemma":[0.00001071436,0.0001813438,0.0006856855,0.003840724,0.0001618028,0.001062628,0.00004967797,0.0002192765,0.004819392,0.0009645644,0.9879751,0.00002906439],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003913166,0.9977144,0.0004235567,0.0001067678,0.0001421607,0.00001183361,0.00003299646,0.00001741685,0.00115966],"genre_scores_gemma":[0.0009406706,0.9977961,0.0004953564,0.00007981933,0.00006637353,0.00001176142,0.00004734192,0.000003401127,0.0005591246],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003243835,"threshold_uncertainty_score":0.01085168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615718383955571,"score_gpt":0.3324481115155413,"score_spread":0.3062909276759855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}