{"id":"W4413127918","doi":"10.3390/vaccines13080853","title":"Freeze-Drying of mRNA-LNPs Vaccines: A Review","year":2025,"lang":"en","type":"review","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Bee Research Fund","keywords":"Messenger RNA; Scalability; Biochemical engineering; Protein stability; Freeze-drying; Nanotechnology; Process (computing); Computer science; Chemistry; Materials science; Engineering; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002045042,0.0004799746,0.001661772,0.0001628067,0.00004180659,0.00001521878,0.0006986963,0.0003694899,0.0001216558],"category_scores_gemma":[0.0003051832,0.0003698589,0.000839886,0.0003547684,0.00001278992,0.000003841853,0.0003206807,0.0001722761,0.00004328079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001276651,"about_ca_system_score_gemma":0.0003552862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003047862,"about_ca_topic_score_gemma":0.0000283789,"domain_scores_codex":[0.998033,0.0001249617,0.0008809252,0.0005755565,0.0001189317,0.0002665958],"domain_scores_gemma":[0.998272,0.00005094499,0.000467839,0.000926396,0.0002218656,0.00006097878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001298871,0.00004809273,0.00002630727,0.1342649,0.0003864335,0.000005362934,0.000003521151,3.523683e-7,0.0003276362,0.00001457117,0.08010074,0.7848091],"study_design_scores_gemma":[0.0001227863,0.0001087106,0.000003829164,0.07743956,0.0007939787,0.00002497738,0.000004327402,2.212286e-7,0.0006882991,0.00001110952,0.920482,0.0003201928],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006584596,0.9972586,0.00003528013,0.00004323208,0.0004006002,0.0006242375,0.00008519482,0.00001591256,0.00147107],"genre_scores_gemma":[0.00002171336,0.9944827,0.00009146493,0.0002780816,0.0003928549,0.0001213585,0.0004639827,0.00003929186,0.004108569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8403813,"threshold_uncertainty_score":0.9998753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615718383955571,"score_gpt":0.3324481115155413,"score_spread":0.3062909276759855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}