{"id":"W4413128047","doi":"10.1101/2025.08.08.668983","title":"Pervasive Chromosomal Instability Drives the Karyotypic Evolution of Hypodiploid Tumours","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"European Research Council; Science Foundation Ireland; Higher Education Authority","keywords":"Chromosome instability; Instability; Genome instability; Biology; Genetics; Gene; Chromosome; DNA; Physics; DNA damage; Mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017192,0.000207981,0.0002669628,0.0008768143,0.0002167862,0.0005671605,0.0001932535,0.000296127,0.001398097],"category_scores_gemma":[0.0007242037,0.0001660043,0.0001607569,0.000722628,0.0003120334,0.0002980088,0.0005770706,0.0003415063,0.0003393143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522173,"about_ca_system_score_gemma":0.0001863549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006613851,"about_ca_topic_score_gemma":0.001097035,"domain_scores_codex":[0.9998566,0.00001655883,0.00001241847,0.00004676112,0.00004044387,0.00002723313],"domain_scores_gemma":[0.9992532,0.0001375047,0.0003926411,0.00006437477,0.00006920112,0.00008304157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002474546,0.00001524308,0.08792521,0.00008957879,0.00004436215,0.0002754586,0.0001070841,0.0003831765,0.9043607,0.0001656934,0.00006471191,0.006321527],"study_design_scores_gemma":[0.00001213529,0.000223745,0.8996881,0.00001896677,0.00007036173,0.003161498,0.0002089731,0.001853575,0.09218787,0.0004068899,0.002153224,0.00001482287],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960996,0.0005874513,0.002149329,0.0000338571,0.000002688871,0.0000130794,0.0004166678,0.00005088592,0.0006464469],"genre_scores_gemma":[0.9971813,0.0003976255,0.001302749,0.00003257261,0.00000453188,0.00001312706,0.0007356593,0.00001866254,0.0003138121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398097,"threshold_uncertainty_score":0.004677057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138725421968488,"score_gpt":0.2326860263172981,"score_spread":0.2212987720976132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}