{"id":"W4413128153","doi":"10.1101/2025.08.08.669345","title":"Development of a genetically encoded melanocortin sensor for high sensitivity intravital imaging","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Melanocortin; Sensitivity (control systems); Computer science; Neuroscience; Biology; Endocrinology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808492,0.0003540671,0.0002598887,0.0001707134,0.0001028589,0.000261279,0.0004799407,0.0007269117,0.0006256212],"category_scores_gemma":[0.0001437345,0.0001835466,0.0002518813,0.0001199131,0.0001672893,0.000313386,0.000263077,0.0004855831,0.0003101953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003956689,"about_ca_system_score_gemma":0.0001656672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006256605,"about_ca_topic_score_gemma":0.0005821929,"domain_scores_codex":[0.9998978,0.00001110923,0.000006519772,0.00003712405,0.00002647972,0.00002093384],"domain_scores_gemma":[0.9999077,0.00001598089,0.00002785552,0.000009212892,0.00002165609,0.0000175363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004441252,0.00000480218,0.00001383486,0.00001102635,0.000001170137,0.00001144575,0.000003140271,0.00004376358,0.9990947,0.00005727318,0.00003061651,0.0007237679],"study_design_scores_gemma":[0.000003999759,0.00006192099,0.0002671241,0.000002761078,0.000004351049,0.00008106963,0.000006040038,0.004223965,0.9940508,0.00002259415,0.001268114,0.000007117196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7881486,0.001352215,0.2055416,0.0004284725,0.0001412754,0.0002238508,0.0005790751,0.00113546,0.002449483],"genre_scores_gemma":[0.8137413,0.0007571044,0.1803204,0.0002561521,0.00002453385,0.0002391711,0.0005634871,0.00008352476,0.004014353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007269117,"threshold_uncertainty_score":0.002870798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008986477172027895,"score_gpt":0.23434055619081,"score_spread":0.2253540790187822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}