{"id":"W4413129745","doi":"10.1111/acel.70191","title":"Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre for Interdisciplinary Research in Rehabilitation; Université de Montréal; McGill University; Christie (Canada); Centre Hospitalier de l’Université de Montréal; Université du Québec à Trois-Rivières; Quebec Rehabilitation Research Network; Université du Québec à Montréal; Group for Research in Decision Analysis; Institut Universitaire de Gériatrie de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Taurine; Biology; Healthy aging; Endocrinology; Internal medicine; Gerontology; Biochemistry; Medicine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009319157,0.0000998996,0.000106011,0.00007448542,0.00003697607,0.000008235665,0.0001509791,0.00004289443,0.00001464603],"category_scores_gemma":[0.00001735456,0.000102194,0.00005089167,0.0001282972,0.0000556161,0.000005237277,0.0001502484,0.00006177232,0.000006609074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000186669,"about_ca_system_score_gemma":0.00007029439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125568,"about_ca_topic_score_gemma":0.00001182309,"domain_scores_codex":[0.9993071,0.00002524579,0.0001669111,0.0002527506,0.00007565696,0.0001723461],"domain_scores_gemma":[0.9996594,0.00001035868,0.00004687124,0.0002355427,0.00002336197,0.00002451067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008231357,0.0001160087,0.00902988,0.00004781302,0.000007015702,0.00001300285,0.0001784115,0.00006557471,0.9898725,0.00008946423,0.0002142606,0.0003578353],"study_design_scores_gemma":[0.0003227283,0.00005900541,0.001661495,0.0001374514,0.000006771772,0.000001371967,0.0003093882,0.00001860433,0.9956325,0.00002836649,0.001723109,0.00009926772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825171,0.009117983,0.00009068113,0.00007762257,0.00007299141,0.00008683055,0.000001236366,0.000006842914,0.008028774],"genre_scores_gemma":[0.9980652,0.0003627379,0.0001673175,0.0002047668,0.00003468627,0.000006941357,0.0000140615,0.000007938526,0.001136295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01554822,"threshold_uncertainty_score":0.416735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009607218939794559,"score_gpt":0.2828031203168934,"score_spread":0.2731959013770988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}