{"id":"W4413138916","doi":"10.1021/acs.jmedchem.5c01417","title":"Novel Inhibitors of <i>Plasmodium</i> Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and <i>In Vivo</i> Efficacy in a Humanized Mouse Malaria Infection Model","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"NHLBI Division of Intramural Research; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; University of Cape Town; Medicines for Malaria Venture; African Academy of Sciences; University of Capetown; South African Medical Research Council; Royal Society; National Research Foundation; UK Research and Innovation; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Government of the United Kingdom","keywords":"Plasmodium falciparum; Plasmodium berghei; Malaria; Pharmacology; Artemisinin; In vivo; Plasmodium (life cycle); Kinase; Chemistry; Biology; Biochemistry; Immunology; Parasite hosting; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008399596,0.0003833771,0.0002428033,0.0001778211,0.00007930696,0.0001541879,0.0001926508,0.0001418362,0.001034884],"category_scores_gemma":[0.00005470032,0.00009991488,0.0001489796,0.0001157994,0.0001068055,0.0001628608,0.0000767124,0.0003946219,0.0002224681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001956144,"about_ca_system_score_gemma":0.0001797092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004855653,"about_ca_topic_score_gemma":0.001152535,"domain_scores_codex":[0.9999645,0.000004765156,0.000003154789,0.000006975349,0.000008256104,0.00001250927],"domain_scores_gemma":[0.9999729,0.000002751411,0.000008862626,0.000002125011,0.000004251754,0.000009106466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000500162,0.0001634578,0.0001195863,0.00008655649,0.00001295636,0.00006950268,0.00001481217,0.0002689415,0.9892439,0.0001747709,0.0003293371,0.009016156],"study_design_scores_gemma":[0.0002754076,0.004375872,0.002667505,0.00001185762,0.00004893585,0.0005923576,0.00001228994,0.001027069,0.9844127,0.00004677049,0.00651898,0.00001020739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842239,0.003934043,0.006328141,0.0001924284,0.00005247511,0.000154338,0.0008835327,0.0002618039,0.003969382],"genre_scores_gemma":[0.981339,0.004438353,0.007340032,0.0001323498,0.00002230849,0.0001307593,0.001447471,0.00002814002,0.005121579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034884,"threshold_uncertainty_score":0.003462017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117304836671985,"score_gpt":0.2682375254640952,"score_spread":0.2570644770973754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}