{"id":"W4413139183","doi":"10.1152/ajprenal.00158.2025","title":"Impaired vascular function in patients with chronic kidney disease who have elevated symmetric dimethylarginine but not asymmetric dimethylarginine","year":2025,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Asymmetric dimethylarginine; Medicine; Internal medicine; Pulse wave velocity; Kidney disease; Renal function; Cardiology; Endocrinology; Reactive hyperemia; Blood pressure; Blood flow; Arginine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004453364,0.0001713245,0.0002760955,0.0003848489,0.0002164099,0.0003564898,0.0001275838,0.0003270435,0.0007414038],"category_scores_gemma":[0.001459807,0.00008940414,0.0002198372,0.0004538656,0.000196108,0.0003304015,0.000229069,0.0004748581,0.00008537597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315255,"about_ca_system_score_gemma":0.000183579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222079,"about_ca_topic_score_gemma":0.002500681,"domain_scores_codex":[0.999832,0.00006625207,0.00001808043,0.00002945165,0.00002189208,0.00003217298],"domain_scores_gemma":[0.9992669,0.0002307114,0.0002269602,0.00004193848,0.00006100565,0.0001724735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004599444,0.00005526899,0.9966273,0.00001217548,0.00003978709,0.00009943495,0.00005359036,0.00003988373,0.0005750125,0.00002538469,0.0000364731,0.001975715],"study_design_scores_gemma":[0.000009834971,0.0001888969,0.9991421,0.000004539951,0.00002675479,0.0001725781,0.00007983734,0.0001664756,0.00008319078,0.00005100976,0.00007194977,0.000002897682],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992344,0.0003549255,0.00005689318,0.00003974205,0.000006124718,0.00000208664,0.0000532425,0.000001361924,0.0002511883],"genre_scores_gemma":[0.9997261,0.00008159229,0.00005385895,0.00001981328,0.00001131031,0.000001598952,0.00004846508,2.62395e-7,0.00005686502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222079,"threshold_uncertainty_score":0.002480209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004558232506929702,"score_gpt":0.2318088968685508,"score_spread":0.2272506643616211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}