{"id":"W4413139605","doi":"10.1002/mdc3.70222","title":"Levodopa‐Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the <scp>COSMOS</scp> Study","year":2025,"lang":"en","type":"article","venue":"Movement Disorders Clinical Practice","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Krembil Foundation; Toronto Western Hospital","funders":"Allergan; AOP Orphan; Ipsen; H. Lundbeck A/S; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Kommunfullmäktige, Stockholms Stad; Boston Scientific Corporation; European Commission; Sanofi; University of Toronto; AbbVie; EVER Neuro Pharma; Teva Pharmaceutical Industries; GlaxoSmithKline","keywords":"Dyskinesia; Parkinson's disease; Levodopa; Medicine; Paroxysmal dyskinesia; Post-hoc analysis; Carbidopa; Internal medicine; Physical therapy; Anesthesia; Psychology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005211966,0.001473224,0.003734618,0.0004641976,0.0004267663,0.0009977891,0.0006991279,0.0007879786,0.003303867],"category_scores_gemma":[0.003336553,0.0003927606,0.005058421,0.0005173387,0.0004939615,0.0006157747,0.0006160846,0.001299843,0.0004126311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005780818,"about_ca_system_score_gemma":0.00103622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140738,"about_ca_topic_score_gemma":0.003263445,"domain_scores_codex":[0.9975921,0.001336576,0.0001999646,0.0003181249,0.0002553277,0.0002979918],"domain_scores_gemma":[0.9956131,0.001664943,0.001056495,0.0005522671,0.0004544642,0.0006586765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9365005,0.004642966,0.02672568,0.0006481115,0.01572733,0.0001060002,0.00009292825,0.0003642912,0.002803244,0.00003259333,0.001155487,0.01120081],"study_design_scores_gemma":[0.2179145,0.3218423,0.4263463,0.0001269559,0.02747109,0.0002005192,0.0001897606,0.001432954,0.002052324,0.00009662949,0.002242875,0.0000837915],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949616,0.001887975,0.0001642606,0.00006875294,0.00008013365,0.0005511236,0.001607939,0.00002953682,0.0006485409],"genre_scores_gemma":[0.9944831,0.0006740674,0.0003416601,0.0001367565,0.000136228,0.0006724379,0.002716199,0.00001639635,0.0008231648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005211966,"threshold_uncertainty_score":0.02756381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206573467909354,"score_gpt":0.3495675213110179,"score_spread":0.3275017866319243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}